श्री चित्रा तिरुनाल आयुर्विज्ञान और प्रौद्योगिकी संस्थान, त्रिवेंद्रम
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum
Main objective of the division is to take up and ensure high standard research in the field of nanomaterials for Bionanophotonics. The lab’s main areas of research themes include development and application of biomaterials, mainly bionanomaterials in the field of MR, CT and optical imaging and photodynamic and photothermal therapy. It is a comparatively new lab which also mentors the need of all laser based activities of the institute, both therapeutic and diagnostic and other biomedical application. We also work in the use of Spectroscopic techniques and spectral mapping and imaging for the early diagnosis of various diseases and the classification and discrimination of different pathologies using these techniques. These works focus on the hypothesis that the concept of optical pathology will be practical in the near future.
The department of Biophotonics and Imaging is mainly involved in the development of nanomaterials for biomedical applications mainly in the field of sensing, therapy and imaging. We have already designed a gold quantum cluster based biosensor for the detection of urea from whole blood. We have also developed several systems which can be used as MRI contrast agents. This includes both T1 and T2 contrast agents. Fluorescence spectroscopic techniques developed in the lab very effectively differentiates normal and diseased tissues with very high selectivity and sensitivity. The technique has been demonstrated successfully in the brain tumor tissue, oral tissue and in the clinical set up of oral cavity disorders. Other ongoing work of the lab are quantum dot-CNT system for imaging and therapy, zinc detection using nanoprobes, iron oxide based MRI contrast agents, Gold nanorods for PDT etc. Other research work based on various applications of lasers in medicine including standardisation of laser based therapeutic and diagnostic procedures for clinical applications is also going on. The department is also engaged in the development of low cost diagnostic systems using fluorescence and diffuse reflectance spectra and imaging. In vivo and ex vivo Fluorescence Spectroscopy, Imaging and Image processing also form part of our work.