The effects of sleep manipulation on the various cognitive parameters including anxiety, emotions, learning and memory are studied employing various behavioral tests in animals. The effect of sleep restriction on spatial memory is tested using the radial arm maze (8 arms). Treatment induced anxiety is measured using elevated plus-maze, open field and light-dark chamber test. The different variables (e.g., total locomotion in the open field and closed-arm entries in the plus-maze, time spent in light and dark chamber etc) are analyzed using ANYMAZE software with videotracking system.
Neonatal anxiety testing: Ultrasonic Vocalizations (USVs) recorder
The effect of prenatal sleep deprivation on offspring is tested through recording their anxiety calls. The Ultrasonic vocalizations in neonates are used to quantify the emotional state in growing pups to study developmental plasticity. Sleep and temperature monitoring in human
Setup for sleep, actigraphy and multi-channel temperature recordings in human is soon coming up. The ambulatory PSG simultaneous with temperature monitoring from various sites of body are designed to understand interrelationship between sleep and body temperatures during normal and acute insomnia conditions. This would help in establishing the optimal ambient temperature required in eliciting and maintaining a good night's sleep. The study design translates into a potential non-pharmacological intervention in management of primary insomnia in different age groups. Actigraphy will provide insight into circadian patterns for insomnia and circadian rhythm disorders. Services
Testing of herbal products for sleep in animal models
Educational Activities: To organize workshops, schools and conferences in area of Sleep and Neurosciences
IBRO-APRC Neuroscience SCHOOL 2019: Dr Kamalesh K Gulia, SIC of Division of Sleep Research, organized IBRO-APRC SCHOOL 2019: International Neuroscience School on Advanced Techniques to Explore the Functions of Normal & Diseased Brain from 22 nd April to 6 th May 2019, BMT Wing, SCTIMST, Trivandrum, Kerala, India
Asian Sleep Research Society congress, ASRS2014: Dr Kamalesh K Gulia, SIC of Division of Sleep Research (then named as Sleep Disorders Research Laboratory) organized ASRS-2014 International conference at Kovalam during September 22-24, 2014. It was attended by delegates, Sleep Medicine experts and Sleep Researchers from 16 countries including Japan, USA, Australia, Finland, Singapore, China, Taiwan, Georgia, France, Switzerland, Germany, Russia, Turkey, Israel and India.
National Sleep Medicine workshop, NMSC2010 was conducted to provide introduction to basic sleep science, the technical and clinical aspects of sleep medicine. The program was organized for general practitioners, neurotechnicians and basic scientists in Kerala and southern India to bring awareness for Sleep Medicine and Research.
To organize Conferences on Sleep in order to generate wide-spread interest among Neuro-biologists and clinicians to take up research programmes to improve the basic knowledge of human sleep and sleep disorders in our country. These activities at national forum are aimed to promote Sleep Research, generate interdisciplinary teams to develop important diagnostic and effective therapeutic strategies at low cost for masses. Projects
Completed Projects: Research
Basic Research: To study neural dynamics in brain after sleep deprivation during pregnancy and in adults using animal models and simulation protocols in human. To identify the role of sleep during different phases of development in cognitive programming. To look for mechanism that interlinks sleep and body temperature, sleep and cardiac autonomic system in conditions of sleep restriction during various phases of development, and scientific evaluation of herbal principles for regulation of sleep.
Translational Research: Evaluation of ambient temperature manipulation as a non-pharmacological intervention for treatment of primary insomnia and to find inflammatory markers after acute and chronic sleep deprivation. To provide evidences for Yoga-nidra mechanism for improving the sleep and wellbeing.
To design, fabricate and evaluate prototype for sleep monitoring system. Staff
Division of Sleep Research Research collaborators:
Dr. Sapna Erat Sreedharan, Additional Professor (Neurology), SCTIMST
Dr. Namboodiri Narayanan KK, Professor (Cardiology Department), SCTIMST
Dr. Jayasree, Sc G (Biophotonics & imaging Lab, BMT wing)
Er. Jitinkrishnan, Er C (Div. of Medical Instrumentation Lab), SCTIMST
Dr. Anugya Bhatt, Sc F (Thrombosis Research Unit, BMT wing)
Dr. Manoj G, Sc E (Div. of Artificial Internal Organs, BMT Wing)