Point of care detection of Human papilloma virus using loop mediated amplification of DNA

Currently PAP smear is the initial test carried out for cervical cancer detection. This method has very low sensitivity. The technology developed by the Institute involves Loop mediated amplification (LAMP) based technique of nucleic acid for detecting HPV 16/18 types. The method has shown high specificity of detection for HPV types when tested in the research laboratory.

The kit needs to be evaluated in clinical samples and for which discussions have been initiated with TATA Memorial Centre, Mumbai.

Involvement of industrial partner is required for clinical evaluation and further regulatory approvals followed by manufacturing

Point of care detection of Human papilloma virus using RNA based technology is also under development. Industry interest is also invited for co-development on the same

For research applications

Epidermal dermal construct with fibroblast and keratinocytes. Construct can be printed of different sizes with different layers of fibroblast and keratinocytes.

Two patent applications filed

Bioink formulation was optimized and characterized. Seeding density, media composition culture conditions were optimized for skin construct. Construct can be printed in any shapes (square, circle, rectangle, triangle)
Preliminary study on 24 rats were done

For lung isolation and selective ventilation

The universal airway device is a single lumen endotracheal tube (ETT) incorporating a left ventilating eye that can be used along with a bronchial blocker for isolation and selective ventilation of one lung. The device has the following advantages: i) Unlike the predicate double lumen tube, which is larger in size, the proposed device is a single lumen tube with modification and can be used even in patients with difficult airway ii) Unlike conventional single lumen tube with bronchial blocker, the proposed device prevents displacement of bronchial blocker, once the blocker has been securely positioned.

Certificate of Registration of Design granted :

In vitro evaluation using human trachea model completed. in silico analysis (Ansys R18.2) was performed for visualizing the air flow during one lung ventilation using the device.
Clinical evaluation to be undertaken with Industry collaboration.

In vivo evaluation, clinical evaluation, regulatory approvals and manufacturing
(An industry having manufacturing facility of Endotracheal tubes is preferred)

HRIDAY defibrillator is low cost portable disposable defibrillator for the management of cardiac arrest victims for both Paediatric (50 joules) and Adult (150 joules)..It is mainly aiming to readily available in low cost via Ambulances,Taxis,small nursing homes, clinics, pharmacy for use.

HRIDAY portable defibrillator is an external portable defibrillator for both Pediatric and Adult. Train of shocks can be delivered with the stored energy. The casing will have a facility to view the heart rhythm rhythm via small display. User need only to switch on the device and system will monitor the ECG of the patient connected via 3 lead ECG cables. User can select either Pediatric (50 Joule) or Adult (150 Joule) option by individual switches at a time Train of 6 shocks can be delivered and after each shocks system monitor the ECG and if patient revert back it can simply stop the shock process.

Technical Details:

TRL -4

The proposed system undergoes various trials and safety test according to ISO 7010- E010 on the Division of Clinical Engineering of Sree Chitra Tirunal Institute of medical science and Technology (SCTIMST). The energy levels of both Adult and Pediatric discharged biphasic wave is analysed, the output waveform is validated with Digital Oscilloscope to confirm the Biphasic Truncated exponential with desired rise time and peak.
Electrical safety validated through Electrical Safety Analyzer.

Industry should ready to make the product as per safety and test standards suggesting the medical standards Commercial product which includes all the features of existing prototype and additionally some features like: