Dr. Umashankar P. R.
Scientist 'G' & Scientist-in-Charge
Phone : 0471 2520226

Academic Qualifications

PhD in Regenerative Medicine, (2011- Division of Implant Biology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, India).

Master of Veterinary Science. In Veterinary Pathology, (2001- Department of Pathology, College of Veterinary and Animal Sciences , Mannuthy, Trichur, India

Bachelor of Veterinary science and Animal Husbandry, (1994- College of Veterinary and Animal Sciences , Mannuthy, Trichur, India

Professional Record

Scientist F (Veterinary), SCTIMST, Thiruvananthapuram, 2012 continuing

Scientist E (Veterinary), SCTIMST, Thiruvananthapuram, 2008- 2012

Scientist D (Veterinary), SCTIMST, Thiruvananthapuram,2004 -2008

Veterinary Scientist C , SCTIMST, Thiruvananthapuram, 2000 -2004

Veterinary Surgeon, SCTIMST, -1995 to 2000 April

Veterinary Surgeon, Department of Animal Husbandry, Kerala. 1994.

Awards

Appreciation award from Department of Animal Husbandry, Government of Kerala (2007), for transfer of technology 'A filed kit for testing antibiotic sensitivity for veterinary application'.

Area of Interest

Medical device translational studies such as "Proof of concept" and Preclinical evaluation of medical devices in animal models.

Development of decellularised/ heparin cross-linked processed animal tissue for cardiovascular application.

Current Activities

Preclinical evaluation of biodegradable drug eluting coronary stent and non-invasive coronary blood flow monitor in porcine coronary artery model. drug eluting coronary stents for Industry.

Development of decellularised/ non-calcifying glutaraldehyde cross-linked / heparin cross-linked animal tissue such bovine/ buffalo pericardium, jugular vein, and saphenous vein for cardiovascular application.

Patents

Indian patent, granted Title: A field kit for testing antibiotic sensitivity of mastitic milk Application number: 942/MAS/2001 date 21-11-2001

Indian patent, under examination Title: A process for non-detergent based decellularisation of animal tissue for therapeutic human implantation' Application no. 2113/CHE/2008 dated 29-08-08

PCT patent Title: Biocompatible and biodegradable biopolymer matrix Application no: PCT/IN2008/000818 Publication date: 11-06-2009.

US patent Title: Biocompatible and biodegradable biopolymer matrix Application no: 12/746,625, date 8th Dec 2008. Publication no: 2010/0260845 A1

European patent Application EP2231134 Title: Biocompatible and biodegradable biopolymer matrix Application no: EP20080857894 dated 12-08-2008 Publication date: 29-9-2010

Indian patent applied Title: Single step method for covalently linking heparin to decellularised tissue. Application no. 4529/CHE/2012 dated 30-10-2012

Indian patent applied Title: Processed bovine pericardial valved conduit and method of its fabrication. Application no. 4044/CHE/2015, 4th August 2015

Membership

Indian Veterinary Association

Indian Society for Veterinary Surgery

Indian Association for Veterinary Pathology

Society for Biomaterials and Artificial Organs, India

Society for Tissue Engineering and Regenerative Medicine, India

Material Research Society of India

On-going Projects

Application of decellularised bovine pericardium for fabrication of a novel valved conduit for RVOT reconstruction in sheep model

Team

Dr. Sachin J Shenoy,Scientist D (Veterinary)

Dr. Dayamon D Mathew, CHVF (Veterinary)

Smt. Smitha P, Technical Assistant (Anesthesia)

Sri. Prem Mohan, Technical Assistant (Lab)

Sri. Manoj Kumar, Animal care taker

Sri. Biju V, Animal care taker

Publications

Article

1
Umashankar PR, Sabareeswaran A and Sachin J Shenoy., Long term healing of mildly crosslinked decellularised bovine pericardial aortic patch, JBMR-Part B, 2016, DOI:10.1002/jbm.b.33755
2
P Suvaneeth, NN Divakaran, PR Umashankar, N Narayanan, MJ Abraham, C Divya and Martin J, In vitro characterization of differently processed decellularised bovine pericardium, LJ Livestock Science, 2015, 7:13-18
3
Harikrishnan VS and Umashankar PR., Cerebral protection for the preclinical evaluation of a vascular graft in sheep carotid artery model, Scandinavian Journal of laboratory Animal Sciences , 2015, 41(3):1-8.
4
Parvathy Thampi, Divakaran Nair, Lalithakunjamma R, Vijayan N, Syam Venugopal and Umashankar Ramachandra, Pathological Effects of Processed Bovine Pericardial Scaffolds?A Comparative In Vivo Evaluation, Artificial Organs , 2013, 37(7):600-605
5
Umashankar P.R, Arun T and Kumari.T.V, Effect of chronic Inflammation and immune response on regeneration induced by decellularised bovine pericardium., J Biomed Mater Res Part A , 2013, 101A: 2202-2209
6
Lekshmi Vidhya, Sachin J Shenoy and Umashankar P.R., Feed induced chronic copper toxicosis in stall fed sheep., Int. J. Livest. Res , 2012, 2(3):219-222
7
Sujesh S, Rajeev A, Shenoy Sachin J, PR Umashankar, Muraleedharan CV, International Journal of Biomedical Engineering and Technology, International Journal of Biomedical Engineering and Technology, 2012, 10(1-10):70-83.
8
Indu N.N. ?Observation of Hypokalaemia in conjunction with respiratory Aakalosis in Anaesthetised Goats?Sachin Shenoy.J , Lekshmi.V, Umashankar P.R., Observation of hypokalemia in conjunction with respiratory alkalosis in anesthetised goats., Indian Veterinary Journal, 2012, 89(9):51-53
9
Mathew V Kurian, Payanam R Umasankar, Arumugam Sabareeswaran, Sachin J Shenoy, Vijayakumar Subban and Mathew K Joseph, A new concept in the sewing rings for mechanical heart valves., Asian Cardiovasc Thorac Ann, 2012, 20:409-417
10
P.R. Umashankar, Mohanan PV and Kumari TV., Glutaraldehyde treatment elicits toxic response compared to decellularisation in bovine pericardium, Toxicology International, 2012, 19(1):51-58.