PhD: in Biotechnology, Center for Biotechnology, Anna University, Chennai. 1995

MSc . Microbiology, Faculty of Medicine, MG University, Kottayam. 1988

BSc. Zoolgy (Main) Physics, Chemistry (subsidiary)1984

Scientist G & Head, Division of Microbial Technology, SCTIMST Joined as Scientist C in 1997 and established the Division of Microbial Technology then known as Division of Microbiology.

Lecturer and Head, Department of Microbiology, Sree Sankara College Kalady, Kochi, Kerala. 1995 - 1997

Received the Best Poster award in researcher category for " Development of an invitro testing model for aerosols and drugs" at International conference on New age Science & technology for sustainable development and Third annual conference of Indian JSPS alumni association 2012.

Received the Best Poster award for "Surfactant gene mRNA modulation in Three dimensional culture of alveolar cells" at 24th Kerala Science Congress 2012.

Received the Best Poster abstract award for poster abstract Titled "Lung cell sheets from temperature responsive culture dishes - an Ideal candidate for artificial lung tissue construct". At Engineering Tissue growth 2002 conference in Pittsburgh, Pennsylvania, USA from March 19th - 22nd 2002

Qualified the Joint CSIR- UGC JRF examination 1988 and was awarded JRF / SRF from 1990 -1995.

First rank in M.Sc. Microbiology (faculty of Medicine) in 1988 from Mahatma Gandhi University, Kottayam, Kerala.

Rameshwardas Birla Samarak Kosh fellowship for M.Sc

University Merit Scholarship for B.Sc. and Pre-degree.

Received the prestigious JSPS (Japanese Society for Promotion of Science) post doctoral fellowship from 2000 to 2002.

1. Cell?material?microbial interactions 2. Molecular dynamics in Bacterial biofilms and Immune modulation. 3. Three-dimensional hybrid artificial tissue models like lung and gut models for studying the molecular biology of respiratory diseases, the effect of aerosolized materials like drugs, pollutants etc. 4. Development of rapid diagnostic kits for infectious diseases. 5. Isolation and development of new anti-microbials / antimicrobial coatings for therapeutics 6. Quality management systems and microbiological evaluations of medical devices and biomaterials

Research activities involves studying material - cell - bacterial interactions in order to understand mechanisms of origin and persistence of Medical device related infections and for developing preventive strategies.

Use of three dimensional tissue engineered models to understand the molecular mechanisms involved cell material interactions and its effect on bacterial pathogenesis.

Immunomodulation by Pseudomonas BiofilmsPulmonary fibrosis-role of micro to nano sized particles a common component in airStudy the modulations in molecular mechanisms of Klebsiella pneumonia infectionDevelopment of new therapeutics and in vitro diagnostics for infectious diseases.

4

Post doctoral fellow with JSPS PDF (Japanese society for Promotion of Science post doctoral fellowship) at Institute of Advanced Biomedical Engineering and Sciences, Tokyo Women's Medical University, Japan from 2000- 2002

Received the JSPS Bridge fellowship in 2015.

Membership in a number of National and international societies like American society for Microbiology, Life member of MRSI, SBAOI, TERMIS, AMI, IAMM, Indian JSPS alumni Association and General secretary South Chapter.

Member of Board of studies for Microbiology, Kerala University, Member BOS Biotechnology, Cochin University of Science and Technology and examiner for PhD at Mahatma Gandhi university, Anna University etc

Validation study of Urinary Tract infection Rapid diagnostic kit with antibiotic sensitivity ? Rapidogram at health facilities of West Bengal. ? - with M/s Agappe diagnostics as Industrial collaborator funded by ICMR, Govt of India.

DBT - Sahaj Project - National Translational Research Facility for Biomaterials, Medical devices & In vitro diagnostics funded by DBT Govt. of India as PI

Development of rapid UTI diagnostic kit with antibiotic sensitivity. Funded by DST , Govt. of India. completed in 2012 as PI

?Delineating mechanisms of biofilm formation in urinary catheters: characterization of the role of E.coli secretory proteins and influence of environmental signals. Funded by KSCSTE , Govt. of Kerala. completed in 2009 as PI

Tissue engineered hybrid artificial lung Model for Testing pollutants and drugs funded by DBT , Govt. of India. completed in 2010 as PI

Epithelial -mesenchymal interactions in Tissue engineered hybrid artificial lung - role of angiogenic factors funded by DBT , Govt. of India. completed in 2012 as PI

Development and evaluation antimicrobial silver oxide coated latex material for use as urinary catheter? funded by SCTIMST was completed in 2000 as PI.

M.Sc Projects guided: 1. A study of bacterial adhesion to uncoated and silver oxide coated latex urinary catheter. 2. Studies on prevalence of antibiotic resistance in isolates from retrieved Foleys catheters. 3. Study factors favoring bacterial adhesion and analyses of protein expression in biofilms. 4. Studies of slime production in gram positive cocci isolated from implants retrieved from patients. 5. ?Study of mechanisms of pathogenesis of Staphylococcus species in Implant associated Infections?. 6. To study the effect of drugs like Bleomycin and Dexamethasone on a co-culture model of pulmonary alveolar-fibroblast cells.

M Phil projects guided 1. Influence of cephalosporin and fluoroquinolone antibiotics on quorum sensing system in Pseudomonas sp. 2. Biofilm formation and immunemodulation by Acinetobacter baumanii on endotracheal tubes: an in vitro study. 3. Influence of catheter and E.coli biofilm on Peripheral Blood Mononuclear Cell culture 4. Support of pneumocyte specific properties by different scaffolds under dynamic condition. 5. Tobacco induced alveolar epithelial injury and role of retinoic acid in its repair: an in vitro analysis. 6. Effect of tobacco extract in inducing oxidative stress in lung pathophysiology an invitro analysis.

M Tech Projects guided: 1. An in vitro analysis of Pseudomonas aeruginosa infection in lung epithelial cells.

MDS projects guided: 1. Elimination of Candida albicans biofilm in radicular dentin by intracanal medications - an in vitro study. 2. Comparative evaluation of anti-bacterial effect of three root canal irrigants on Enterococcus faecalis biofilm- an invitro study

PDF programme: Study the modulations in molecular mechanisms of Klebsiella pneumonia infection using three dimensional hybrid artificial lung model

PhD completed degree awarded: 1. Immune modulations in Pseudomonas aeruginosa biofilms.

As Co-guide in PhD programme at IIT Madras : Biodegradable polymer based drug delivery system to prevent the development and persistence of biofilms on medical implants

Patent granted : 1. Rapid antibiotic sensitivity test kit for urinary tract infection (UTI) A Maya Nandkumar & Pradeep Kumar SS

DBT Sahaj project scientist

Mr Pradeep Kumar SS Senior scientific assistant

PhD students 3

A. Maya, and A. Balakrishnan. Interaction of shed filarial proteins on growth regulation of normal lung epithelial cells. In: Proceedings of international symposium on virus cell - interaction: cellular and molecular response, held at Indian Veterinary Research Institute, Bangalore, India during 22nd-24th Nov. 1993.

Arun Balakrishnan, Peter Williams, A. Maya, S. Usha and Kunthala Jayaraman. Modulation of cell signaling pathways in epithelial cells during proliferation and infection. In: The proceedings of International Symposium of cell signaling and ova-transplantation, New Delhi, Nov.17-24 (1994).

A. Maya Nandkumar, S Pradeep Kumar, HV Eswer and RN Bhattacharya. Prevalence of Bacterial Biofilms on Foley's catheters collected from Patients and its significance. In the proceedings of the 20th Annual conference of Indian association of Biomedical Scientists from 1-3rd October 1999.

Maya A Nandkumar, Yamato Masayuki, Kushida Ai, Isoi Yuki, Utsumi Mika, Kikuchi Akihiko and Okano Teruo. Lung cell sheets from temperature responsive dishes - an ideal candidate for lung tissue construct. Presented at the Engineering Tissue Growth 2002 conference in Pittsburgh, Pennsylvania, USA from March 19 th to 21st 2002.

Maya A Nandkumar, Pradeep Kumar SS and Lydia Augustine. " Significance of slime production by Staphylococcus epidermidis on colony morphology on Congo red medium" in the Proceedings of 25th Annual conference of Indian Association of Bio Medical Scientists at Chennai from 7 - 10th Oct 2004.

A Maya Nandkumar. "Electron microscopic analysis of alveolar cell type morphology in heterotypic culture system" in the proceedings of National conference on electron microscopy at XXVIII Annual meeting of Electron Microscopic Society of India (EMSI) on April 19 -21st 2006. at Regional Research Laboratory, Trivandrum.

Maya A Nandkumar. "Isolation of Rat adult alveolar stem cells and its maintenance in culture". In Proceedings of International Society for stem cell Research (ISSCR) 5th Annual Meeting at Cairns Queensland, Australia (17th - 20th June 2007).

Maya A Nandkumar. "Type II alveolar stem cell isolation, differentiation and survival in culture". In proceedings of International conference on stem cell Tissue Engineering and regenerative medicine - Frontier conclave 2007 at Chennai (30th Nov - 2nd Dec 2007).

Afzal A, S Ignatius Rex, Pradeep Kumar SS, A. Maya Nandkumar. "Anti-fungal action of three different root canal irrigants on Fungal biofilm - an in vitro study" XXII FODI & XV IES Annual conference at Kualalumpur Malaysia (23rd to 25th November 2007).

Afzal A Pradeep Kumar SS and A. Maya Nandkumar "Antibacterial effect of three root canal irrigants on E.faecalis Biofilm- An invitro study" 29th Annual Conference of Indian Association of Biomedical Scientists in 2008.

Unnikrishnan S, Lynda V Thomas, Prabha D Nair and A Maya Nandkumar "A biohybrid copolymer scaffold for lung Tissue engineering" International conference on Medical Materials, Devices, and Regenerative Medicine 2008 Nepal.

Anupama, Pradeep Kumar SS and A MayaNandkumar "Influence of glucose in Catheter Associated Urinary Tract infection (CAUTI)" In the proceedings of 50th Annual meeting of AMI on December, 2009.

Suja lakshmi S, Pradeep Kumar SS & A Maya Nandkumar 'Influence Latex Foleys urinary catheters on peripheral blood mononuclear cell cultures.' In the proceedings of International conference on Recent Trends In Material Science 2010.

Suja lakshmi S, Pradeep Kumar SS & A Maya Nandkumar "Influence of E. coli biofilm on gene expression in human peripheral blood mononuclear cells (PBMC)" 51st annual AMI (Association of Microbiologists, India) conference from 14th to 17th Dec 2010.

Pradeep Kumar SS*, Remesh Babu V $, A. Maya Nandkumar "Survival of E.coli biofilm under dynamic flow of antibiotics, a challenge to antibiotic sensitivity testing of biofilms" 2011

Ashna U*, Lynda.V.Thomas?, Prabha D Nair? & A Maya Nandkumar . A comparative study of surfactant protein expression on static versus dynamic culture of lung cells in International

Ancymol G R*, Pradeep kumar S S*, PR Umashankar$, A Maya Nandkumar "Evaluation of Tissue Engineered Products for Freedom from Microbial Contamination" International conference on Futuristic Science and Technology in Frontier areas and 2nd Annual conference of Indian JSPS Alumni association in Thiruvananthapuram from 5 -6th August 2011.

Anish Mohan, Ashna. U, Pradeep Kumar SS and A. Maya Nandkumar "Influence of different scaffold materials on surfactant synthesis by alveolar epithelial cells International conference on Futuristic Science and Technology in Frontier areas and 2nd Annual conference of Indian JSPS Alumni association in Thiruvananthapuram from 5 -6th August 2011.

Ashna. U and A. Maya Nandkumar "Effect of bleomycin on a co-culture model of pulmonary alveolar - fibroblast cells" International conference on Futuristic Science and Technology in Frontier areas and 2nd Annual conference of Indian JSPS Alumni association in Thiruvananthapuram from 5 -6th August 2011.

Ashna U, Lynda.V.Thomas?, Prabha D Nair? & A Maya Nandkumar. Surfactant gene mRNA modulation in three dimensional cultures of alveolar cells. 24th Kerala Science Congress 2012. . Awarded the best poster in Biotechnology

Ashna U, Lynda.V.Thomas?, Prabha D Nair? & A Maya Nandkumar. Development of an in vitro testing model for aerosols and drugs. International Conference on new Age science and technology for sustainable development and 3rd annual conference of Indian JSPS Alumni association. 2012. Second award for Best poster in researcher category.

Ashna. U and A. Maya Nandkumar. Analysis of alveolar epithelial - mesenchymal interactions on challenge with bleomycin using electric cell substrate impedance sensing. 25th Kerala Science Congress 2013.

Girish SP, Pradeep Kumar SS, and A Maya Nandkumar "Virulence gene modulations in Pseudomonas aeruginosa during infection of epithelial cell" at International conferance International conference on fronteirs in energy, environment, health and material research (EEMR 2013.)12 to 13th August 2013.

Pradeep Kumar SS, and A Maya Nandkumar "Immunomodulations by E.coli biofilms" at 28th International conferance of Chemotherapy and Infections at 5th to 8th June 2013 at Yokohama, Japan

A. Maya Nandkumar, "Developing In-vitro mimics for testing medical devices, pharmaceuticals and toxins" in the proceedings of 24th National conference (SBAOI) at Kathmandu, Nepal from 11-01-14 to 13-01-14.

Pradeep Kumar SS, Manoj Komath, A. Maya Nandkumar, "DLC coating - A promising Anti-infective surface for Biomedical applications" in the proceedings of IJAA conference MHS at Chennai from 07-08-2014 to 08-08-2014.

Keerthi.S, Pradeep kumar SS, Kavita Raja, A. Maya Nandkumar, "Role of Antibiotics in biofilm formation by Pseudomonas isolates." In the proceedings of the 7th International Congress on Environmental Research (ICER-14) at Bangalore from 26-12-14 to 28-12-14.

A. Maya Nandkumar, Keerthi.S, "Role of VEGF in regaining lung functionality on tobacco induced alveolar epithelial injury." In the proceedings of the Indo-Australian conference on Biomaterials, Tissue Engineering Drug Delivery Systems and Regenerative Medicine (BI-TERM - 2015) at Chennai from 05-02-15 to 07-02-15.

U. Mareena George, Keerthi.S, Pradeep Kumar SS, A. Maya Nandkumar, "Cell - Cell Interaction and retinoic acid effect on surfactant production in A549 cell lines." In the proceedings of the Indo-Australian conference on Biomaterials, Tissue Engineering Drug Delivery Systems and Regenerative Medicine (BI-TERM - 2015) at Chennai from 05-02-15 to 07-02-15.

A Maya Nandkumar. Attended BIO4Apps 2015 - International conference on Bioelectroncs, Biosensors, BioMedical Devices, BioMEMS/NEMS and applications from Dec 9th to 11 2015 in Kyushu University, Japan and delivered a talk titled " Surface modification as a strategy to prevent Medical device related infections"

Amalu Navas, Pradeep Kumar SS, , A. Maya Nandkumar, "Pulmonary fibrosis: Nanoparticles as inducers in shift to the aberrant wound healing" In the proceedings of the International Conference on "Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery & Regenerative Medicine" at IIT Delhi, April 15-17, 2016 (BI-TERM - 2016)

Biby T Edwin, Pradeep Kumar SS, , A. Maya Nandkumar, "Role of antibiotics on Klebsiella Biofilm formation: An understanding of implant infection." In the proceedings of the International Conference on "Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery & Regenerative Medicine" at IIT Delhi, April 15-17, 2016 (BI-TERM - 2016)

Keerthi S, Pradeep Kumar SS, , A. Maya Nandkumar, "eDNA- A diagnostic tool for biofilm infections" In the proceedings of the International Conference on "Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery & Regenerative Medicine" at IIT Delhi, April 15-17, 2016 (BI-TERM - 2016)

Pradeep Kumar SS, Manoj Komath, A. Maya Nandkumar, "Carbon based coatings for medical device surfaces to resist Microbial Biofilm formation." In the proceedings of the International Conference on "Biomaterials, Biodiagnostics, Tissue Engineering, Drug Delivery & Regenerative Medicine" at IIT Delhi, April 15-17, 2016 (BI-TERM - 2016)

Govindraj Perumal, A Maya Nandkumar and Mukesh Doble "Circumin based polymer blend Nanofibrous scaffold for wound dressing applications. In Proceedings of the 10th World Biomaterials Conference at Montreal Canada 17 -22 May 2016.

Dr A Maya Nandkumar "Clinical significance of Biofilms" at MAHAMICROCON 2012 and XVII Maharashtra Chapter of Indian Association of Medical Microbiologists 2012.

Dr A Maya Nandkumar "Three dimensional Tissue engineered lung constructs as test systems for development of novel drugs and therapeutics" Third Euro-India International Conference on Nanomedicine and Tissue Engineering (ICNT 2013) 9-11 August 2013, Kottayam, Kerala, India

Delivered an invited lecture in Microbiology, Microbial biofilms and Material surfaces. On 19.1.2015 to undergraduate students in the Department of Material Science & Research Institute of Environment and information Sciences, Yokohama National University, Yokohama 240-8501, Japan

Delivered an invited lecture to Graduate and doctoral students at Yokohama National University titled 'Cell - Material -Microbial - interactions." On 24.11.2015

Delivered Plenary talk on "Medical device related infections and bacterial biofilms" at 13th International symposium on Biosciences and Nanotechnology held at Bio-Nano electronics Research Centre at Toyo university from 26 -28th Nov 2015.

Attended the 6th Indian Scientists Association in Japan (ISAJ) at Indian Embassy in Tokyo, Japan and delivered a invited lecture titled "Microbial Biofilms and Medical devices" on 6th Dec 2015.

As co-guide in IIT Madras: Biodegradable polymer based drug delivery system to prevent the development and persistence of biofilms on medical implants

MDS dissertation supervised: 2. Comparative evaluation of anti-bacterial effect of three root canal irrigants on Enterococcus faecalis biofilm- an invitro study

MDS dissertation supervised: 1. Elimination of Candida albicans biofilm in radicular dentin by intra-canal medications - an in vitro study.

4. Effect of tobacco extract in inducing oxidative stress in lung pathophysiology an invitro analysis

3. Tobacco induced alveolar epithelial injury and role of retinoic acid in its repair: an in vitro study

2. Support of pneumocyte specific properties by different scaffolds under dynamic condition

1. Influence of catheter and E.coli biofilm on Peripheral Blood Mononuclear Cell culture

1. An in vitro analysis of Pseudomonas aeruginosa infection in lung epithelial cells.

11. Sudhin Thampi, A. Maya Nandkumar, Vignesh Muthuvijayan, and Ramesh Parameswaran. Differential Adhesive and Bioactive Properties of the Polymeric Surface Coated with Graphene Oxide Thin Film. Applied material and interphases (ACS); 9(5),4498 - 4508 (2017).

10. Govindaraj Perumal, S. Pappuru, D. Chakraborty, A.M. Nandkumar, D.K. Chand, M. Doble. Synthesis and characterization of curcumin loaded PLA-applications. Materials Science and Engineering: C, 76 (2017) 1196-1204.

9. Govindaraj Perumal, B. Ramasamy, A.M. Nandkumar, M. Doble. Influence of magnesium particles and Pluronic F127 on compressive strength and cytocompatibility of nanocomposite injectable and moldable beads for bone regeneration. Journal of the mechanical behavior of biomedical materials, 88 (2018) 453-462.

8. Govindaraj Perumal, B. Ramasamy, A.M. Nandkumar, M. Doble. Nanostructure coated AZ31 magnesium cylindrical mesh cage for potential long bone segmental defect repair applications. Colloids and Surfaces B: Biointerfaces,172 (2018) 690-698.

7. Govindaraj Perumal, B. Ramasamy, A.M. Nandkumar, S Dhanasekaran, S Ramasamy and M. Doble. Bilayered nanostructure coating on AZ31 magnesium alloy implants for the healing of critical-sized rabbit femoral segmental bone defects. Nanomedicine, Nanotechnology, Biology and Medicine 29 (2020) 102232.

6. Subhash Neyyattinkara Neelakandan, Aneesh Sukesan, Jijo Jerald, Vivek Parayath Uthaman Vipin Dev Vasudevan, Pradeep Kumar Soman Pillai Sarojini Amma ? Maya A. Nandkumar, Muraleedharan Chirathodi Vayalappil. `Chitra Ultraviolet?C?Based Facemask Disposal Bin. Transactions of the Indian National Academy of Engineering.

5. Remya Bijoy, Naresh Kasoju and A Maya Nandkumar. SARS-CoV-2 detection by quantitative PCR: a technical note on concepts, practical considerations and safety aspects for beginners. Accepted for publication in Trends in biomaterials and artificial organs (2022) : 36(1), 68-76.

4. Keerthi S1, Vishnu Raj M2, and Maya Nandkumar A1,* Role of Inflammasome-Mediated Pyroptosis as a Mechanism of Pathogenicity in Pseudomonas Biofilms. Arch Microbiol immunol 2022:6(1):7 ? 19. DOI: 10.26502/ ami.93650073

3. eDNA Release, a Contributor to Antibiotic Resistance in Medical Device-related Infections: Pseudomonas Biofilms, A Case Study. Keerthi, S., & Nandkumar, A. M. Trends in Biomaterials & Artificial Organs, 36(2), 77- 83(2022) . https://www.biomaterials.org.in/tibao/index.php/tibao/article/view/612.

2. Electrical cell substrate impedance sensing ( ECIS ) as a tool to study microbial cell interactions., Keerthi, S., Nandkumar, A Maya (2022). In vitro models (0123456789) : doi:10.1007/s44164-022-00029-6

1. Electric Cell-Substrate Impedance Sensing (ECIS) for Analyzing the Effect of Environmental Pollutants - A Study of Diesel Exhaust Nanoparticles. Amalu Navas, Maya Nandkumar A. J Environ Sci Public Health 2022;6 (2):189-203 DOI: 10.26502/jesph.96120166

VTM technology transferred to 3 companies: 1. Levram lifesciences Pvt Ltd. 2. Origin diagnostics and Research Kerala. 3. Ultimate moulds and Products, Thrissur

1. Developed rapid UTI diagnostic kit with antibiogram and Technology transferred to M/s Agappe diagnostics.