Dr. Madhusoodanan U. K.
Associate Professor
Phone : 0471-2524478 (O), 8157897692

PhD-Department of Biochemistry, Indian Institute of Science, Bangalore, 2009

MSc-Medical Biochemistry, KMC Manipal, Manipal University (MAHE), 2002

BSc-Microbiology, Kannur University, 1999

Associate Professor-Department of Biochemistry, SCTIMST, January 2021-

Assistant Professor - Department of Biochemistry, SCTIMST, October 2017-December 2020

Research Scientist - Molecular Oncology, MVRCCRI, Calicut, 2017

Post Doctoral fellow - IFOM-The FIRC Institute of Molecular Oncology, MIlan, Italy- 2009-2016

JRF-NET CSIR and ICMR (2003)

Invited speaker in international conferences

Protein posttranslational modifications and their role in neuronal DNA repair and cell survival pathways

Genetic and Molecular basis of rare inherited disorders

Circulating exosomal-miRNAs as disease indicators for neurodegenerative diseases

Development of biochemical assays for rare neurodegenerative diseases diagnosis

Post doctoral fellowship funded by European Research Council (ERC-2009-StG ERC-SG) - Regulatory mechanisms coordinating replication integrity and intra-S repair

Welcome trust Visiting fellow (February to April 2010), NCBR, Masaryk University, Brno, Czech Republic

Executive Committee Member, Indian Society for Extracellular Vesicles (InSEV)

Life member, Society of Biological Chemists (SBC-India)

Life member, Academy of Cardiovascular Sciences

Principal Investigator: Identification and characterization of Ubiquitin and SUMO modified exosomal proteins in Parkinsons Disease Patients-ICMR (2021-2024)

Principal Investigator: Absolute measurement of Glucocerobrosidase activity for monitoring lysosomal dysfunction in Parkinsons disease-ICMR (2023-2025)

Co-PI: Contemporary outcomes in cardiac channelopathies guided by Genotype-based management-ICMR (2021-2025)

Co-I: Prognostic value of circulating microRNAs in Heart Failure-ICMR (2021-2023)

Co-I: ICMR-Center for Advanced Research and Excellence (CARE) in heart failure-ICMR (2019-2024)

Co-I: Genetic Architecture of Parkinsons disease-The Michael J. Fox Foundation (2019-2022)

Principal Investigator: Detection of Circulating Exosomal-Ubiquitinated Proteins in Parkinsons Disease-Seed Fund-SCTIMST (2019-2021)

Co-PI: Establishment of A Biorepository of Epilepsy and Investigating the Relation of Multidrug Transporter Polymorphism with Fetal Malformations Based on The Repository -DBT (2017-2020)

Co-Invest: Development of real time RT-PCR assay for detection of SARS-CoV2-TDF fund-SCTIMST (2020-2021)

MSc project students: 5

Four days Training in Laboratory Quality Management System (IA & QMS as per ISO15189) accredited by National Accreditation Board for Education and Training (NABET), Quality council of India

Organizing committee member: Biochemistry Talks- Department of Biochemistry, SCTIMST

Scientific Affairs Committee member: 39th Annual Conference of Indian Association for Cancer Research (IACR-2020) at Trivandrum on 5th -7th February 2020

Faculty and moderator for a session in The Heart Failure Conflux, organised by the Heart Failure Assiciation of India

PhD student: Aishwarya babu

JRF: Achanya S Jayan

5th Chromosome Stability Meeting, Dec 14-18, IISER, Trivandrum

39th Annual Conference of Indian Association for Cancer Research (IACR-2020) at Trivandrum on 5th -7th February 2020.

10th DAE-BRNS Life Science Symposium-2019 (LSS-2019), BARC, Mumbai, March 28-30, 2019

Chromosome Stability 2018 meeting, December 14-17, 2018, JNCASR, Bangalore

10th Young Investigator Meeting (YIM 2018), Mar 5-9, 2018, Trivandrum

Indo-French Conference (Indo-French Centre for Promotion of Advanced Research, IFCPAR/CEFIPRA), December 4-5, 2017, Bangalore.

CME on the occasion of World Microbiome Day, organized by Department of Medical Microbiology & Department of Medical Biochemistry, AKG Co-operative Institute of Health Sciences, Kannur on June 27, 2022

Emerging Trends and Fronters in Applied Microbiology and Biotechnology, organised by St. Pius X College, Rajapuram, Kasaragod on March 10th 2022 (Online)

Emerging trends in Neurotherapeutics, organized by at the department of Biochemistry, St. Thomas College, Palai on December 15th, 2021 (online)

Special lecture on Basic Concepts of Diet and Nutrition, Department of Yoga Studies, Central University of Kerala, October 2020, online.

National Workshop Biovista-2020, Department of Biochemistry, Malankara Catholic College, Kaliakkavilai, Tamil Nadu, on February 4th, 2020.

National Symposium on Advances in Biosciences(SEIB 2019), Inter University Centre for Evolutionary and Integrative Biology (iCEIB) of the University of Kerala, April 27, 2019

National seminar on Omics approaches in Biotechnology at the department of biotechnology, Govt college, Kariavattom on February 15th, 2019

National seminar on New horizons in cancer treatment and prevention: from bench to bedside, Mar 16-17, SN college, Kollam, 2018

Cardio-vascular pathology update, Mar 11-12, SCTIMST, 2018

Reviewer: Journal of Cell Communication and Signaling, Asian Pacific Journal of Tropical Medicine, Cell and Tissue Banking, Journal of Chemistry, Human Gene


Asish Vijayaraghavan, Madhusoodanan Urulangodi, Karthika Ajit, Soumya Sundaram, Syam Krishnan , Movement disorders in GRIA2-related disorder - expanding the genetic spectrum of developmental dyskinetic encephalopathy. , Movement Disorders Clinical Practice, 2023, , doi: 10.1002/mdc3.13797
Soumya Krishnamoorthy, Gurpreet Singh, Sapna Erat Sreedharan, Deepa Damayanthi, Srinivas Gopala, Madhusoodanan UK, Sylaja PN , Soluble ST2 Predicts Poor Functional Outcome in Acute Ischemic Stroke Patients., Cerebrovasc Dis Extra, 2023, 13(1):33-40, doi: 10.1159/000529512.
Karthika Ajit, Srutji S Nair, Sethu Madhavan Anjali, Pravi Vidyadharan, Madhusoodanan Urulangodi, Ramshekhar N Menon, Soumya Sundaram , A genotype-phenotype description in two Indian patients: broadening the spectrum in VRK1-related complex motor disorders. , Neurology and Clinical Neuroscience, 2023, , https://doi.org/10.1111/ncn3.12694
Krishnamoorthy S, Sylaja PN, Sreedharan SE, Singh G, Damayanthi D, Gopala S, Madhusoodanan UK, Ramachandran H.J , Biomarkers predict hemorrhagic transformation and stroke severity after acute ischemic stroke. , J Stroke Cerebrovasc Dis, 2023, 32(1):106875, doi: 10.1016/j.jstrokecerebrovasdis.2022.106875
Bhavya B, Anand CR, Madhusoodanan Urulangodi, Sreelakshmi K, Deepti AN, Girish RM, Krishnakumar K, Easwer HV, Srinivas G , The mutant isocitrate dehydrogenase 1 product, 2-hydroxyglutarate, activates MutT homolog 1 in glioma cells via the augmentation of reactive oxygen species levels, World Academy of Sciences Journal, 2022, , https://doi.org/10.3892/wasj.2022.174
F. Alfia, Manna Jose, Soumya V Chandrasekharan, Soumya Sundaram, Madhusoodanan Urulangodi, Bejoy Thomas, Ashalatha Radhakrishnan, Moinak Banerjee, Ramshekhar N Menon, C12orf57 pathogenic variants: a unique cause of developmental encephalopathy in a south Indian child., Journal of Genetics, 2022, 101 (3), https://doi.org/10.1007/s12041-022-01371-0
Linda Koshy, Jeemon Panniyammakal, Sanjay Ganapathi, Madhuma M, Madhusoodanan Urulangodi, Meenakshi Sharma, Harikrishnan Sivadasanpillai, Association of South Asian-specific MYBPC3?25bp deletion polymorphism and cardiomyopathy: A systematic review and meta-analysis., Meta Gene, 2021, 28, 100883, https://www.sciencedirect.com/science/article/pii/S2214540021000347
Bhavya B, Easwer HV, Vilanilam GC, Anand CR, Sreelakshmi K, Madhusoodanan Urulangodi, et al.,, MutT Homolog1 has multifaceted role in glioma and is under the apparent orchestration by Hypoxia Inducible factor1 alpha, Life Sci., 2021, 2021 Jan 1;264:118673., https://pubmed.ncbi.nlm.nih.gov/33130078/
Anja Waizenegger, Madhusoodanan Urulangodi, Carl Lehmann, Reyes TAC, Saugar I, Tercero JA, Szakal B, Branzei D., Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity, Nature Communications, 2020, 11, 5746., https://www.nature.com/articles/s41467-020-19503-4
Madhusoodanan Urulangodi*, Abhishek Mohanty, DNA Damage Response and Repair Pathway Modulation by Non-Histone Protein Methylation: Implications in Neurodegeneration, J Cell Commun Signal, 2020, 14 (1):31-45, 2020, https://pubmed.ncbi.nlm.nih.gov/31749026/