Dr. Manju S.
Scientist 'D'
Phone :

PhD, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India, 2012

Master of Science in Chemistry (Polymer Sciences), Mahatma Gandhi University, Kottayam, Kerala, India, 2004

Bachelor of Science in Chemistry, Kerala University, Thiruvananthapuram, Kerala, India, 2002

Scientist D, Sree Chitra Tirunal Institite for Medical Sciences and Technology, Trivandrum, December 2018-till date

Adjunct Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, October 2017-November 2018

Research Associate, Dept. Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, July 2017-November 2018

Postdoctoral Fellow, Dept. Craniofacial Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, July 2015-June 2017

Postdoctoral Research Associate, Dept. Pharmaceutical Sciences, South Dakota State University, Brookings, South Dakota, January 2014-June 2015

Postdoctoral Research Associate, Dept. Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, July 2012-2013

ESB Rudolf Cimdins Scholarships, European Society for Biomaterials (ESB), Lausanne, Switzerland, 2009

Certificate of outstanding contribution in Reviewing , Carbohydrate Polymers (Elsevier 2018)

Har Gobind Khorana-Innovative Young Biotechnologist Award (IYBA) 2020

Senior Research Fellowship (SRF) 2010, Council of Scientific and Industrial Research (CSIR), New Delhi, India, 2010

Travel Award, Department of Biotechnology, New Delhi, India, 2009

Polymer formulations for biomedical applications

Antibiofilm coatings on medical implants

Nanogels, Dental materials

Teaching Polymeric Biomaterials and Dental Materials to M.Tech Clinical Engineering Students

Develop mucoadhesive bandages for oral drug delivery

Antibacterial/Antibiofilm coating on biomedical devices

Develop glass-Ionomer Cements for dental applications

Nair, Devatha P; Simberg,Dimitri; M. Saraswathy, Targeted Nanogel for Urinary Bladder Therapies, PCT/US2018/024049. (International Publication Number: WO/2018/175899)

Nair, Devatha P; Kahook, Malik Y; Stansbury, Jeffrey; Torbati, Amir; Marks, Zefram; M, Saraswathy, Nanogels for Ophthalmic Applications, PCT/US16/025319. (International Publication Number: WO 2016/ 161144 A1)

Nair, Devatha P; Kahook, Malik Y; Torbati, Amir; M, Saraswathy, Copolymer Formulation for Lenses, PCT/US2016/013675. (International Publication Number: WO 2016/ 115507 A1)

Material Research Society of India (MRSI)

The Society of Polymer Science India (SPSI)

Indian Society for Dental Research(ISDR)

Society for Biomaterials and Artificial Organs (India)

Asian Polymer Association (APA)

Development of modified Glass Ionomer Cement to Improve Mechanical Properties (Funding agency; SRG, SERB 2020-2022)

Mucoadhesive Bandages for desquamtive gingivitis (Funding agency; TDF, SCTIMST)

Development of plasticizer free acrylic denture soft liners using nanogel additives (Funding agency; IYBA, DBT 2021-2023)

Chitra AcryloSorb: Respiratory fluid secretion solidification system (Funding: TRC, SCTIMST); Transfer the technology to Romsons Scientific and Surgical Pvt Ltd, Agra

Division of Dental Products

Strategies to mitigate plasticizer migrations in crosslinked polymer networks, Third International Conference on Advanced Materials (ICAM 2019) 9-11 August 2019, Kottayam, Kerala, India.

New Trends in Dental Materials; October 15, 2019, CDE Program on Bio-Materials Applications in Dentistry organized by PMS college of Dental Science and Research along with SCTIMST, Trivandrum

Chitra ACryloSorb; Respiratory Secretion Solidification System; October 31, 2020, Webinar organized by MRSI, Trivandrum Chapter

Peer-reviewed scientific articles # 20 ; Total impact factor: 119 ; Google scholar citations: 1143; h index: 14; US Patent Applications # 3; Book Chapters # 2

S. Manju and K. Sreenivasan, Functionalized Nanoparticle for Targeted Drug Delivery (Book: Biointegration of Medical Implant materials Science and design, Publisher: Woodhead Publishing limited, UK)

M. Saraswathy and David Oupicky, Endo-lysosomal escape into the cytosol (Book: Drug Delivery Across Physiological Barriers, Publisher: Pan Stanford Publishing Pvt. Ltd)

1. C. R. Joshi, V. Raghavan, S. Vijayaraghavalu, Y. Gao, M. Saraswathy, V. Labhasetwar, A. Ghorpade, Reaching for the Stars in the Brain: Polymer-Mediated Gene Delivery to Human Astrocytes, Molecular Therapy-Nucleic Acids (2018), Vol.12, pp. 645-657 [impact factor: 5.919]

2. T. D Ovidio, R. Roberts, D. Gautam, Z. Marks, M. Saraswathy, J. Stansbury and D. Nair, Photopolymerization Kinetics of Methyl methacrylate with reactive and inert Nanogels, Journal of the Mechanical Behavior of Biomedical Materials (2018), Vol.85, pp. 218-224 [impact factor: 3.485]

3. M. Saraswathy, J. Stansbury and D. Nair, Thiol-functionalized nanogels as reactive plasticizers for crosslinked polymer networks, Journal of the Mechanical Behavior of Biomedical Materials (2017), Vol. 74, pp. 296-303 [impact factor: 3.485]

4. J. Griffin, S. Cheng, M. Saraswathy, D. Nair, T. Hayashi, D. Carson and D. Simberg, Cell penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury, Nanomedicine:NBM (2017), Vol. 13, pp.1925-1932 [impact factor: 5.57]

5. M. Saraswathy, J. Stansbury and D. Nair, Synthesis and Characterization of Water Dispersible Siloxane Nanogels: A Novel Technique to Control Surface Characteristics and Drug Release Kinetics, Journal of Material Chemistry B (2016) Vol. 4, pp. 5299-5307 [impact factor: 5.047]

6. M. Saraswathy, G. T. Knight, Srikanth Pilla, R. S. Ashton and S. Gong, cRGD-conjugated nanoparticles formed by ??CD-PAMAM-PEG for targeted cancer therapy, Colloids and Surfaces B: Biointerfaces (2015) Vol. 126, pp.590-597 [impact factor: 3.973]

7. V.V.K. Venuganti, M. Saraswathy, C. Dwivedi1, R.S. Kaushik, O.P. Perumal. Topical gene silencing by iontophoretic delivery of antisense oligonucleotide-dendrimer nanocomplex: Proof of concept in a skin cancer mouse model, Nanoscale (2015) Vol. 7, pp. 3903-3914 [impact factor: 6.97]

8. M. Saraswathy and S. Gong, Recent developments in the co-delivery of siRNA and small molecule drugs for cancer treatment, Materials Today (2014), Vol 17, pp. 298-306 [impact factor: 24.372]

9. M. Saraswathy and S. Gong, Different strategies to overcome multidrug resistance, Biotechnology Advances (2013), Vol 31, pp. 1397???1407. [impact factor: 12.831]

10. S. Manju and K. Sreenivasan, Enhanced Drug Loading on Magnetic Nanoparticles by Layer-by-Layer Assembly using Drug Conjugates: Blood Compatibility Evaluation and Targeted Drug Delivery into Cancer cells, Langmuir (2011), Vol 27, pp. 14489???14496. [impact factor: 3.683]

11. S. Manju, C. P. Sharma, K. Sreenivasan, Targeted coadministration of sparingly soluble paclitaxel and curcumin into cancer cells by surface engineered magnetic nanoparticles, Journal of Materials chemistry (2011), Vol 21, 2011, pp.15708-15717. [impact factor: 5.047]

12. S. Manju and K.Sreenivasan, Gold Nanoparticles Generated and Stabilized by Water-soluble Curcumin-Polymer Conjugate: Blood Compatibility evaluation and Targeted drug delivery on to Cancer cells, Journal of Colloid and interface Science (2011), Vol 368, pp.144-151. [impact factor: 6.361]

13. S. Manju and K. Sreenivasan, Synthesis and characterization of a cytotoxic cationic polyvinylpyrrolidone-curcumin conjugate, Journal of Pharmaceutical Sciences (2011), Vol 100, pp. 504-511. [impact factor: 3.197]

14. S. Manju and K. Sreenivasan, Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability, Journal of Colloid and interface Science (2011), Vol 359, pp. 318-325. [impact factor: 6.361]

15. S. Manju and K. Sreenivasan, Hollow microcapsules built by Layer by Layer assembly for the encapsulation and sustained release of curcumin, Colloids and Surfaces B: Biointerfaces (2011), Vol 82, pp.588-593. [impact factor: 3.973]

16. S. Manju and K. Sreenivasan, Detection of glucose in synthetic tear fluid using dually functionalized gold nanoparticles, Talanta (2011), Vol 85, pp. 2643-2649. [impact factor: 4.916]

17. M. Saraswathy, Chirathodi Vayalappil Muraleedharan, Adathala Rajeev, Attipettah Jayakrishnan, Roy Joseph, Evaluation of alginate dialdehyde cross-linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft, Journal of Biomedical Materials Research: Part B Applied Biomaterials (2011), Vol. 98B, pp.139-149. [impact factor: 2.674]

18. S. Manju, P. R. Hari, K. Sreenivasan, Fluorescent molecularly imprinted polymer film binds glucose with concomitant changes in fluorescence, Biosensors and Bioelectronics (2010), Vol 26, pp.894-897. [impact factor: 9.518]

19. S. Manju and K. Sreenivasan, Layer-by-Layer modification of Poly (methyl methacrylate) intra ocular lens: Drug delivery applications, Pharmaceutical Development and Technology (2010), Vol 15, pp.379-385. [impact factor: 2.347]

20. S. Manju, M. Antony, K. Sreenivasan, Synthesis and evaluation of hydrogel that binds glucose and releases ciprofloxacin, Journal of Material Science (2010), Vol 45, pp. 4006-4012. [impact factor: 3.442]

Journal of agricultural and food chemistry

Artificial cells, nanomedicine and biotechnology

Research and report in transdermal drug delivery

International journal of nanomedicine

Journal of nanopharmaceutics and drug delivery

Journal of biomedical nanotechnology

Journal of materials chemistry B

New journal of chemistry

Carbohydrate polymers

Journal of colloid and interface Science

Chitra ACryloSorb; Respiratory Secretion Solidification System (Technology transfered to Romsons Scientific and Surgical Pvt. Ltd., Agra, India)