Dr. Manoj Komath
Scientist 'G' & Scientist-in-Charge
Phone : 9387414142

Ph.D., Sardar Patel University, Gujarat, 1995 (Awarded for the Thesis : Metastable Synthesis of Diamond from Liquid and Vapour Phases)

M.Sc. (Physics), Calicut University, Kerala, 1987

B.Sc. (Physics), Calicut University, Kerala, 1985

Scientist G from January 2016 (present position) at the Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum.

Scientist-C (2000-2004); Scientist-D (2004-2008); Scientist-E (2008-2012) and Scientist-F (2012-2016) at the Biomedical Technology Wing, SCTIMST, Trivandrum.

Scientist-B (Adhoc), from December 1998 to December 1999, at the Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum.

Research Associate, from March1996-November 1998, Department of Instrumentation, Indian Institute of Science (IISc) Bangalore

Young Investigators' Award : for the most outstanding presentation of the paper "Calcium Phosphate Cement for Dental Applications" in the Asian Bioceramics Conference, Osaka City University, Osaka, Japan, September 25-27, 2007.

Science Literature Award for the best science book in Malayalam of 2012, instituted by the Kerala State Council for Science, Technology and Environment.

MRSI Best Paper Prize for "Development of fully Injectable Calcium Phosphate Cement for Orthopedic and Dental Applications" published in Bulletin of Materials Science, 2003, Vol 26, p 415.

Best Poster Award for 'Development of a Versatile Drug Eluting Bioactive Bone Filler Cement' in the International Union of Material Research Societies - International Conference in Asia 2013 (IUMRS-ICA 2013) held at Indian Instituite of Science, Banglore during 16-20 December 2013(Presented by Ms.Sandhya S).

Best Poster Award for ?Calcium-Strontium-Silicate Composite Cement for Endodontic Repair ? Design and In Vitro Studies?, in the International Conference on BioMaterials, BioEngineering and BioTheranostics (BIOMET -2018) held at Vellore Institute of Technology during 26-28th July 2018. (Presented by Mr.Nishad KV)

Best Paper Award for ?Click Crosslinking Technique for Generating Bioactive Composite Graded Membrane for Periodontal Treatment?, in the 6th National Conference on Recent Trends in Materials Science and Technology (NCMST-2019) organised by Indian Institute of Space Science and Technology (IIST), Trivandrum, during 18-20 December 2019. (Presented by Mr.Adarsh RK)

Best Poster Award for ?Investigation of Osteogenic Potential of Periodontal Ligament Cells on Phosphate Incorporated Calcium Sulfate Cement ? An In Vitro Study? , in the National Conference on Recent Trends in Materials Science and Technology (NCMST-2020) jointly organized online by the Indian Institute of Space Science Technology, Trivandrum, and the Society for Polymer Science India, Trivandrum Chapter, during 7th to 9th December 2020. (Presented by Ms.Eva C Das)

Working on the translational aspects of biomaterials-based products.

Current interests are - (i) Materials for Regenerative Dentistry, and (ii) Bioceramic Drug Delivery Systems.

Supervising the research and development work in the areas of (i) Ceramic Coatings, (ii) Injectable Bone Cements, and (iii) Implantable Vertebral Spacers.

IIT Delhi - Collaborated for Multi Institutional Program on Peptide Dendrimers.

IISc, Bangalore - Collaborated in Center of Excellence Program

New bioactive structures through polymer modifications for guided tissue regeneration. (Research/PhD work ongoing)

Hybrid bone grafts with load-bearing bioceramic cages and osteoinductive cues for enhanced fracture union.(Research/PhD work ongoing)

Development of biomatrices incorporating specific extracellular vesicles for the regeneration of bone.(Research/PhD work ongoing)

Luminal guidance structures with multi-functional channeling for the regeneration of injured peripheral nerves.(Research/PhD work ongoing)

"Apatitic Bone Cement Composite with Bioactive Glass", Manoj Komath, P R Hari Krishna Varma (Filed in 2000; Granted).

"Injectable Calcium Phosphate Cement for Dental Applications", Manoj Komath, P R Hari Krishna Varma (Filed in 2002; Granted).

"A Bone Filler Cement", Manoj Komath, P R Hari Krishna Varma (Filed on 19/03/2012).

"A Process for the Preparation of Low Dimensional Calcium Sulphate Crystals", Manoj Komath, Suresh Babu Sivadasan, P R Hari Krishna Varma (Filed on 16/4/2012).

"A Process for Making Titanium Bone Implants with Biocompatible and Nanoporous Surface Structure", Rajesh Palangadan, Manoj Komath, P R Hari Krishna Varma (Filed on 02/08/2012).

"A Process for Making Diamond Like Carbon Coating to Prevent Metal Ion Elution from the Surfaces of Medical Devices", Manoj Komath, C V Muraleedharan, G S Bhuvaneshwar (Filed on 15/10/2012).

"A Process for Making Flexible and Adherent Diamond Like Carbon Coating on Vascular Stents and Stent Like Devices to Prevent Metal Ion Elution", Manoj Komath, C V Muraleedharan, G S Bhuvaneshwar (Filed on 19/11/2012)

"An Improved Portable Bassinet with Controlled Infrared Warming Facility for Thermoregulation of Low-Birth-Weight Infants to Achieve Faster Weight Recovery and a Method for the Same", Sarath Sasidharan Nair, Manoj Komath (Filed on 16/10/2015)

"Hydroxyapatite Gel Based Injectable Radio-Opaque Paste For Root Canal Filling", Manoj Komath and P.R.Harikrishna Varma (Filed on 08/12/2015)

"Bioactive Resorbable Electrospun Fiber Mats with Graded Structure for Periodontal Tissue Barrier Applications", Manoj Komath and Anil Kumar PR (Filed on 06/09/2017)

?An Inter Vertebral Spacer Device with a Delivery Instrument Employing a Protracting Pin Mechanism and a Method for Deployment?, Manoj Komath, Sajin Raj RG and V Ramesh Babu (Filed on 14/11/2018)

?A Process for Making Spherical Bioceramic Beads Using Super Hydrophobic Powder Bed?, Suresh Babu S., Manoj Komath and Harikrishna Varma P.R. (Filed on 18/09/2019, No.201941037650)

?Oropharyngeal Swab?, Shiny Velayudhan, Maya Nandkumar, AnilKumar PR and Manoj Komath (Filed on 11/04/2020, No.202041015783)

?A System for Immobilization and Safe Disposal of Respiratory Secretions in Hospitals? Manju S, Manoj Komath, Ajay Prasad and Asha Kishore (Filed on 11/05/2020, No. 202041019872)

?A Structurally and Functionally Graded Porous Membrane-Scaffold for Guided Tissue Regeneration? Sarah Lukhose, Manoj Komath and P Ramesh (Filed on 09/09/2020 No.202041038937)

?Self-Deploying Closure Plug and Delivery Mechanism for Intra-Nasal Endoscopic Repair of Skull-Base Defects? Gijo Raj, Roy Joseph, Prakash Nair and Manoj Komath (Filed on 02/12/2020, No.202041052458)

?Reactive Mist Generating System For Obtaining Nanostructured, Multilayered And Multiphase Calcium Phosphate Coatings In Plasma Spray?, Manoj Komath, Sajin Raj R G, Suresh Babu S and Harikrishna Varma P R. Filed on 03/06/2022

UGC-CSIR Junior and Senior Research (Indian National) Fellowship 1988-1993 (for Doctoral Study)

Life Member, Society for Biomaterials and Artificial Organs, India (SBAOI)

Life Member, Materials Research Society of India (MRSI)

"Translational research on biomaterials for orthopaedic and dental applications" (As a part of Center of Excellence program, Co-ordinated by IISc), as Co-I, supported by DBT (Rs.69,73,000) [2016 onwards]

?Design and validation of products based on bioactive self-setting injectable material for dental tissue regeneration? as PI, DBT-ATGC Scheme (Rs.33,46,085)

"Development of Calcium Sulfate based Injectable Bone Substitutes?, as PI, Department of Science and Technology (SERC) [2010-2012]

"Pulsed laser coating of bioactive ceramic composite on titanium bone implants", State Committee on Science, Technology and Environment (STEC), Kerala [2011-2014]

"Bioresorbable nano porous bioceramic matrices for drug delivery in osteoporosis management", as Co-PI, funded by DST (Rs.31,06,000), [2013-2016]

?Bioactive inter-vertebral spacers for lumbar fusion? (As a part of the National Technical Research Center for Biomedical Devices, co-ordinated by SCTIMST), as PI, supported by DST (Rs.31,23,000) [2016-2018]

"Bioactive material platform for drug delivery in bone" (As a part of the National Technical Research Center for Biomedical Devices, co-ordinated by SCTIMST), as Co-PI, Supported by DST (Rs.58,55,000) [2016-2019]

"Scaffolds Based on Self-assembling Peptide Dendrimers and Resorbable Calcium Phosphates for Endodontic Tissue Regeneration (DBT Task Force in Bioengineering), as PI, funded by DBT (Rs.35,36,617) [2016-2019]

"Bioceramic cages with axially aligned pores as a tricortical bone graft substitute" (As a part of the National Technical Research Center for Biomedical Devices, co-ordinated by SCTIMST) as PI, supported by DST (Rs.14,96,000) [2019-2021]

As a Scientist, gained 22 years of experience in the design and validation of biomedical products, including animal experiments and clinical trials, and technology transfer of the same, at SCTIMST. Independently carried out the development of bioactive bone cement product for orthopaedic and dental applications, which is currently marketed in India.

2017 ? The 6th Asian Biomaterials Congress (International), held during October 25-27, 2017, in Trivandrum, India. Involved as the Organising Secretary.

2019 ? Co-organiser - One-day Workshop for Dental Students on ?Biomaterials ? Application in Industry? in collaboration with PMS College of Dental Science and Research, on 15th October 2019.

Trends in Biomaterials and Artificial Organs (Associate Editor since 2018)

Biomimetic deposition of hydroxyapatite on titanium with help of sol?gel grown calcium pyrophosphate prelayer, S. Sureshbabu, M. Komath, S. M. A. Shibli and H. K. Varma, Materials Res. Innovations, 15:3 (2011) 178.

Pulsed laser deposition of hydroxyapatite on titanium substrate with titania interlayer, P. Rajesh, C. V. Muraleedharan, Manoj Komath and H.K. Varma, J Mater Sci: Mater Med, 22 (2011) 497.

Laser surface modification of titanium substrate for pulsed laser deposition of highly adherent hydroxyapatite, P. Rajesh, C. V. Muraleedharan, Manoj Komath, H.K. Varma, J Mater Sci: Mater Med, 22 (2011) 1671.

Formation of hydroxyapatite coating on titanium at 200?C through pulsed laser deposition followed by hydrothermal treatment, Manoj Komath, P. Rajesh, C V Muraleedharan, H K Varma, R. Reshmi and M K Jayaraj, Bull. Mater. Sci., 34 :2 (2011) 389.

In Situ Formation of Hydroxyapatite -Alpha Tricalcium Phosphate Biphasic Ceramics with Higher Strength and Bioactivity, S. Sureshbabu, Manoj Komath, and H. K.Varma, J. Am. Ceram. Soc., 95: 3 (2012) 915.

Nucleation kinetics of the formation of low dimensional calcium sulfate dihydrate crystals in isopropyl alcohol medium, S. Sandhya, S. Sureshbabu, H. K. Varma, and Manoj Komath, Crystal Research and Technol., 47 (2012) 780.

Synthesis of chemically pure, luminescent Eu3+ doped HAp nanoparticles: a promising fluorescent probe for in vivo imaging applications, K. Hasna, S. Sasanka Kumar, Manoj Komath, Manoj Raama Varma, M. K. Jayaraj and K. Rajeev Kumar, Phys. Chem. Chem. Phys., 15 (2013) 8106.

Calcium phosphate cement as an alternative for formocresol in primary teeth pulpotomies, Bijimole Jose, N Ratnakumari, Mira Mohanty, Varma HK, Manoj Komath, Indian Journal of Dental Research, 24 (2013) 522.

Periapical tissue reaction to calcium phosphate root canal sealer in porcine model, George M Jacob, Ajay Kumar, Jolly Mary Varughese, NO Varghese, PR Harikrishna Varma and Manoj Komath, Indian Journal of Dental Research, 25:1 (2014) 22.

Development of an injectable bioactive bone filler cement with hydrogen orthophosphate incorporated calcium sulfate, Sandhya S, Sureshbabu S, Nishad KV, Varma HK and Manoj Komath. J Mater Sci: Mater Med. 26 (2015) 5355.

Preclinical safety and efficacy evaluation of `BioCaS? bioactive calcium sulfate bone cement, Sandhya S, Mohanan PV, Sabareeswaran A, Varma, HK and Manoj Komath, Biomedical Materials, 12 (2017) 15022.

Synthesis and characterization of low dimensional bioactive monetite by solvent exchange method, K.V. Nishad, S. Sureshbabu, Manoj Komath, G. Unnikrishnan, Materials Letters, 209 (2017) 19.

Diamond-Like Carbon Coating for Corrosion Protection of Metallic Implants, Manoj Komath, Trends Biomater. Artif. Organs, 31:4 (2017) 131.

Self-assembling polymeric dendritic peptide as functional osteogenic matrix for periodontal regeneration scaffolds?an in vitro study. Eva C. Das, Sameer Dhawan, Jisha Babu, PR Anil Kumar, TV Kumary, V Haridas and Manoj Komath, J Periodontal Res, 54 (2019) 468.

Synthetic Osteogenic Matrix using Polymeric Dendritic Peptides for treating Human Periodontal defects - design and in vitro evaluation, Eva C Das, Jisha Babu, Sameer Dhawan, Anil Kumar PR, TV Kumary and V Haridas, Manoj Komath, Materials Today: Proceedings, 15 (2019) 199.

Inducing apatite pre-layer on titanium surface through hydrothermal processing for osseointegration, E B Ansar, K Ravikumar, S Suresh Babu, F B Fernandez, Manoj Komath, Bikramjit Basu , and P R Harikrishna Varma, Mater Sci Eng C Mater Biol Appl, 26 (2019) 110019.

Synthesis of strontium orthosilicate (Sr2SiO4) by sol-gel method for the use in endodontic cements to enhance bioactivity and radiocontrast, Nishad KV, Manoj Komath and Unnikrishnan G, Mater. Res. Express, 6 (2019) 105401.

Calcium sulfate-based bioactive cement for periodontal regeneration: An in vitro study, Eva C Das, T V Kumary, P R Anil Kumar and Manoj Komath, Indian J Dent Res, 30 (2019 ) 558.

In vitro evaluation of the enamel remineralization potential of a dentifrice containing nano calcium strontium apatite, Alex G. Varghese, Adarsh RK, Nishad KV and Manoj Komath, Trends Biomater. Artif. Organs, 33 (2019) 56.

Water dispersible ZnSe/ZnS quantum dots: Assessment of cellular integration, toxicity and bio-distribution, Reshma V G , Rajeev KS , Manoj Komath and Mohanan PV, Journal of Photochemistry and Photobiology, B: Biology, 212 (2020) 112019.

Hydroxyapatite cages with aligned pores for bone grafting ? Seeding of human osteoblast-like cells and their response in dynamic culture, Athira RK, Gayathry G, Anil Kumar PR, Harikrishna Varma PR, Naresh Kasoju and Manoj Komath, Ceramics International, doi.org/10.1016/j.ceramint.2021.07.181.

Porous membranes of quaternized chitosan composited with strontium-based nanobioceramic for periodontal tissue regeneration, Adarsh RK, Shamna NS, Arun Sadasivan, Roy Joseph and Manoj Komath, Journal of Biomaterials Applications, 2021, DOI: 10.1177/08853282211050271.

Isolation and characterization of stem cells from human exfoliated deciduous teeth (SHED) and their potential role in the cytocompatibility evaluation of materials for regenerative dentistry, Eva C. Das, P.R. Anil Kumar, D. Vinod, Jolly Mary Varughese and Manoj Komath, Trends Biomater. Artif. Organs, 36:1 (2022) 4.

Quaternised chitosan composites with in situ precipitated nano calcium phosphate for making bioactive and degradable tissue engineering scaffolds, R. K. Adarsh, Eva C. Das, Gopika V. Gopan, Remya K. R and Manoj Komath, Journal of Polymer Research, 29 (2022) 267, DOI:10.1007/s10965-022-03125-z.

BOOK CHAPTER : Gayathry G, Manoj Komath, D. Shiny Velayudhan, Biomaterials for medical products, Chapter 2, in Biomedical Product and Materials Evaluation : Standards and Ethics, Woodhead Publishing Series in Biomaterials., 2022, p. 25-62, https://doi.org/10.1016/b978-0-12-823966-7.00012-8

BOOK CHAPTER : Eva C. Das, Manoj Komath, P.R. Anil Kumar, Dental Tissue Engineering, Chapter 21 in Tissue Engineering, Editor(s): Chandra P. Sharma, Thomas Chandy, Vinoy Thomas, Finosh G. Thankam, Academic Press, 2022, p. 493-529, https://doi.org/10.1016/B978-0-12-824064-9.00021-6

Polymer modification strategies to develop new bioactive structures for guided tissue regeneration - Mr.Adarsh RK ; (2020)

Biological Evaluation of Biomaterials for Regeneration of Dental Tissues using Tooth Derived Cells - Dr.Eva C Das; Ph D Awarded (2020).

Calcium phosphate cement, Technology transferred to M/s IFGL Bioceramics, Calcutta.

Bioactive calcium sulfate cement, Transferred to M/s G Surgiwear, Shajahanpur.

Portable infant warmer, Technology transferred to M/s HLL Lifecare, Trivandrum.

Bioceramic bone grafts based on Tricalcium phosphate to M/s Onyx, Meerut.

Bioceramic granules and cement for dental application to M/s Prevest DenPro, Jammu.

`AcryloSorb?- Respiratory secretion solidification system to M/s Romsons, Agra.