QualificationsHonors Projects PublicationsPatentsTeam

Dr. Mohanan P. V.

Scientist 'G' & Scientist-in-Charge
Phone :
91-471-2520266 (direct), Lab: 2520246, 356, mob - 91-9446542702
Academic Qualifications

PDF: The University of Tsukuba, Japan (2000-02)

PhD: University of Kerala, India (1997)

MSc: University of Calicut, Kerala, India (1986)

BSc : University of Calicut, Kerala, India (1984)

Professional Record

Scientist -F: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum (2011 to Present)

Scientist-E: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum (2007-11)

Scientist-D: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum (2003-07)

Scientist-C: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum (1998 to 03)

Scientist-B: Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum (1994-98)

Honors

Certificate of appreciation from Hon. Minister of Science and Technology, Govt. of India for the contribution to India getting full adherent status on GLP from OECD , New Delhi (NGCMA, DST, 2011)

Visiting Professor: Graduate School of Interdisciplinary New Science, Toyo University, Japan

Visiting Researcher: Bio Nano Electronics Research Centre, Toyo University, Japan

JSPS Bridge Fellowship, 2012, Japan Society for Promotion of Science, Govt. of Japan

Senior Toxicologist Fellowship' award by the International Union of Toxicology (IUTOX), USA (2010)

JSPS Postdoctoral fellowship award, 2000, Japan Society for the Promotion Sciences, Govt. of Japan

STOX/ASAW-Surajben Jethalal Thaker Prakruti Mandir Gold medal Award (2009)

Shared Thomas Edison Award-2014: Excellent research in Free Radicals and Antioxidants.

Shared Best Poster award at the 2nd International Summit on Toxicology, 7-9 October, 2013, Las Vegas, USA.

Country Correspondent for the World Library of Toxicology, USA, 2010

Certified Biological Safety Specialist, NAMSA, USA, 2009

National GLP Inspector, NGCMA, DST, New Delhi.

Secretary General of Society of Toxicology, India (2006-2012)

Chairman, South Chapter, Indian JSPS Alumni Association (2010-2013).

General Secretary, Indian JSPS Alumni Association (2013-present)

Secretary General, Association of Toxicology, India (2012 to 2013)

Associate Editor: Expert Reviews of Immunology, Vaccines and Informatics [Exp Rev Immunol Vaccine Informat] journal

Editorial Board member: Toxicology International Journal

Editorial Board member: International Journal of Medical Nano Research

Editorial Board member: International Journal of Composite and Constituent Materials

Editorial Board member: International Journals of Nanobiotechnology

Editorial Board member: International Journal of Bioincs and Bio-Materials

Organizing Secretary: Three Days Intensive Residential Training Programme on 'Toxicity, Safety, Biocompatibility Evaluation of Materials, Medical devices and Combination Products', Trivandrum, 17-19 February 2014

Organizing Secretary: International Conference on Futuristic Science and Technology in Frontier areas & 2nd Annual Conference of Indian JSPS Alumni Association (INDO-JAPAN), Thiruvananthapuram, Kerala, India, August 5-6, 2011

Organizing Secretary, INDO-US symposium on GLP: emphasis on medical devices, 5-7, March 2008, Trivandrum

Organizing Secretary: Silver Jubilee Year celebrations of Society of Toxicology and National Symposium on Good Laboratory Practice and regulatory issues, October 28-30, 2004 at SCTIMST, Trivandrum

Awards

Senior Toxicologist Fellowship, 2010, International Union of Toxicology, USA.

Certified Biological Safety Specialist by NAMSA, USA.

STOX/ASAW ? Surajben Jethalal Thaker Prakruti Mandir Gold medal Award (2009).

JSPS Postdoctoral fellowship award, 2000 by the Japan Society for the Promotion Sciences, Govt. of Japan.

Area of Interest

Toxicity/biocompatibility studies of materials and Medical devices

Toxicology of nanomaterials and immunotoxicity

Toxicology of Pharmaceuticals, Agrochemicals and cosmetics

Toxicology of tissue engineered medical products, combinational products

Regulatory Toxicology

Development of alternative test system for animal experimentation.

Good Laboratory Practice and ISO 17025

Development of National GLP Guidelines for Medical devices

Current Activities

Toxicity/biocompatibility studies of materials and Medical devices

Toxicology of nanomaterials, immunotoxicity

Regulatory Toxicology

Development of alternative test system for animal experimentation

Good Laboratory Practice and ISO 17025

On-going Projects

Development of Centrifugal Blood Pump with drive unit and flow meter for extracorporeal cardiopulmonary bypass.

Development of para-corporeal left ventricular assist device

Development of Aortic Stent Graft for endovascular treatment of thoracic aortic aneurysms

Development of a deep brain stimulator system for movement disorders

Bioactive Material Platform for drug delivery in bone

Development of intracranial electrodes for use in acute and chronic electrocorticography

An injectable hydrogel for repair of cartilage injury and growth plate defects

Lint free absorbent dressing for surgical and highly exudating chronic wounds

Alginate scaffold with recombinant growth factors for enhanced wound healing

Development of Nitinol based Occlusion Devices for non-surgical closure of Atrial Septal Defect

Patents

Mohanan PV, Siddharth Banerjee, Muralidharan CV, Lissy K Krishnan, Bhuvaneshwar GS. Development of an 'A Method for evaluating pyrogenicity in vitro and a kit therefor'. Indian Patent: Application No.1028/CHE/2012 A. Publication Date : 15/08/2014

Fellowships

Fellow of Society of Toxicology, India [FST]

Fellow of Academy of Sciences for Animal Welfare [FASc (AW)]

Fellow of Society for Applied Biotechnology (FSAB)

Membership

Life member, Society of Toxicology (STOX), India,

Life Member, Indian JSPS Alumni Association, India

Life member, The Academy of Sciences for animal welfare, India

Life Member, Association of Toxicology, India

Life Member, Indian Society of Toxicology,

Life Member, Environmental Mutagen Society, India,

Life Member, Society for Biomaterials & Artificial Organs, India

Life Member, Materials Research Society of India

Life Member, Society for Tissue Engineering and Regenerative Medicine, India

Member in Indian Chapter of the Society of Quality Assurance (ICSQA) affiliated to International Society of Quality Assurance (SQA)

Team

Dr. Mohanan. PV, Scientist-F & Head, Toxicology Division

Dr. Remya. NS, Scientist-C

Ms. Syama. S, PhD student

Ms. Reshma S Cherian, PhD student

Ms. Sruthi. S, PhD student

Ms. Reshma. V.G, PhD student

Mr. Shaji. S, Supportive staff

Mr. Harikumar. G, Supportive staff

Ms. Amruthakumari V, Supportive staff

Projects Completed

Molecular and immuno-toxicological effects of Dextran coated Ferrite and hydroxyapatite nanomaterials. Nanomission, DST, New Delhi

In Vitro alternative test system development for Ocular Irritation. ICMR, New Delhi

Development of National GLP Guidelines & Identification and selection of National Regulatory Guidelines for Testing and Evaluation of Medical Devices. GLP Monitoring Authority, DST, New Delhi

Evaluation of molecular toxicity of newly developed materials intended for biomedical applications. ICMR, New Delhi.

Development of an In vitro pyrogen test kit: Evaluation of pyrogenicity using human whole blood. DBT, New Delhi

Development of Non-toxic Latex Formulation for Biomedical Applications. DST, New Delhi

90 day sub-chronic toxicity by intraperitoneal implantation of Coated Copper T material in wistar rats

Mammalian erythrocyte Micronucleus test of Physiological saline extract of Coated Copper T device in albino mice

Mammalian Bone marrow chromosome aberration study of Physiological Saline extract of Coated Copper T device in albino mice.

Combined chronic toxicity and carcinogenicity studies of dextran coated ferrite nanomaterial in wistar rats

Combined chronic toxicity and carcinogenicity studies of hydroxyapitate nanomaterial in wistar rats

Mammalian Bone marrow chromosome aberration study of Physiological Saline extract of High Density Polyethylene in albino mice.

Mammalian erythrocyte Micronucleus test of Physiological saline extract of High Density Polyethylene in albino mice

90 day sub-chronic toxicity by intraperitoneal implantation of degradable Polycaprolactone (PCL) based scaffold in wistar rats.

In vivo genotoxicity tests-Mammalian erythrocyte Micronucleus test of Physiological saline extract of ECSIL in albino mice.

In vivo genotoxicity tests: Mammalian Bone marrow chromosome aberration test of Ethanol-Saline extract of ECSIL in albino mice

In vivo genotoxicity tests: Mammalian Bone marrow chromosome aberration test of physiological saline extract of ECSIL in albino mice.

In vivo genotoxicity tests-Mammalian erythrocyte Micronucleus test of Sesame oil extract of ECSIL in albino mice.

Evaluation of the hemostatic efficiency of Poly [?-(1,4)-2-amino-2-deoxy-D-glucosamine], based Haemostatic dressing in albino rabbits

Toxicity study of Stent materials

Acute, sub acute and sub chronic oral toxicity of a composite drug HIVS2004

Repeated dose 90 day Oral toxicity study of Polymeric nanoparticle - NMITLI - BST001 in rats

Biological evaluation of collagen based Biomaterials

Evaluation of the efficacy of Recombinant platelet-derived growth factor on healing of experimentally induced surgical wounds in SD rats.

Publications
1
Gayathri V, Varma HK, Mohanan PV, Integration of Rabbit Adipose Derived Mesenchymal Stem Cells to Hydroxyapatite Burr Hole Button device for bone interface regeneration, International Journal of Biomaterials, 2016, 1067857, doi.org/10.1155/
2
Reshma S Cherian, Syama S, Mohanan PV, Nano-biointeractions of PEGylated and bare reduced graphene oxide on lung alveolar epithelial cells: a comparative in vitro study., Colloids and Surfaces B: Biointerfaces , 2016, 140, 104-116
3
Syama S, Mohanan PV, Safety and biocompatibility of Graphene: A new generation nanomaterial for biomedical application, Int J Biol Macromol, 2016, S0141-8130(16)30118-0. do
4
Sabareeswaran A, Ansar EB, Harikrishna Varma PR, Mohanan PV, Kumary TV, Effect of surface-modified superparamagnetic iron oxide nanoparticles (SPIONS) on mast cell infiltration: An acute in vivo study, Nanomedicine. , 2016, 10.1016/j.nano. 2016.02.0
5
Sheeja LE, Mohanan PV, Hepatotoxicity Evaluation of Dextran stabilized Iron Oxide Nanoparticles in Wistar rats, Int J Pharm, 2016, 16, 30406-9
6
Lissy KK, Juliet BS, Madhumati R, Vimala J, Mohanan PV, Harikrishnan VS, Rabbit snake-bite model to assess safety and efficacy of anti viper chicken antibodies (IgY), American Journal of Clinical and Experimental Medicine, 2015, 3(1): 32-38
7
Sreejith R, Vivekanandan P, Yutaka N, Takahiro F, Seiki I, Toshiaki H, Toru M, Yasushi S, Mohanan PV, Toru Maekawa, D. Sakthikumar, Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties, International Journal of Biological Macromolecules, 2015, 76, 310-319
8
Reshma S.C, Sruthi S, Syama S, Gayathri V, Mohanan P.V, Assessing the systemic toxicity in rabbits after sub acute exposure of known ocular irritant chemicals., Toxicol. Res, 2015, 31(1), 49-59
9
Lekshmy MS, Gayathri V, Sabareeswaran A, Mohanan PV, Induction of oxidative stress and lymphocyte proliferation by nanohydroxyapatite in mice, Journal of Basic & Applied Research International, 2015, 8(3): 202-212
10
Sruthi S, Mohanan PV, Investigation on cellular interactions of astrocytes with Zinc oxide nanoparticles using rat C6 cell line, Colloids and Surfaces B: Biointerfaces , 2015, 133, 1?11