Dr. Sabareeswaran A.
Scientist 'F'
Phone :
0471 2520251

PhD in Nanomedicine, SCTIMST, 2016

Master of Veterinary Science (M.V.Sc- Veterinary pathology); Tamil Nadu Veterinary and Animal sciences University (TANUVAS), Chennai-600007; 2005.

Bachelor of Veterinary Science and Animal Husbandry(B.V.Sc&AH); Tamil Nadu Veterinary and Animal sciences University (TANUVAS), Chennai-600007; 2003.

Scientist - C, SCTIMST, 2006-2010

Scientist - D, SCTIMST, 2010-2014

Scientist - E, SCTIMST, 2014-2017

Scientist - F, SCTIMST, 2017 onward

"Biological safety specialist" by NAMSA Advisory services, USA

Tissue -material interaction, biocompatibility evaluation, preclinical evaluation of medical devices

Nanomedicine, nanoparticles interaction with immune cells, immunopathology, epigenetics

Anna University, Chennai

IIT-Kanpur, UP

RRCAT-Indore, MP

IISc, Bangalore

Evaluation of biocompatibility of materials as per ISO 10993 standards. Materials include metals, polymers, ceramics, composites and natural materials in subcutaneous tissue, muscle and bone of guinea pigs, rats and rabbits.

Preclinical evaluation of medical devices includes coronary stents (bare, drug eluting, degradable), Annuloplasty ring, blood centrifugal pump, Left Ventricular Assist Device, Orthodontic screws, PCL-Gel and Polyurethane based dural substitute, bone graft implants, liquid neuroembolisation agents.

Nanotoxicity evaluation, Evaluation of tissue engineering scaffolds with stem cells, 3D inks and scaffolds

Life member of Indian Association of Veterinary Pathologists (IAVP).

Founder life Member of Materials Research Society of India (MRSI).

Programme Support on Translational Research on Biomaterials for Orthopaedic and Dental applications (2015-2021)

Histopathological evaluation of materials and medical devices developed under Technical research centre(TRC) programme(2016-2021)

Stem Cell Derived Exosome Therapy for Clinical Management of Lung Damage in Critically-ill Corona Viral Pneumonia Patients, funded by SERB, Department of Science and Technology, Govt of India. (Co Investigator) 2020-2021

Biological evaluation of Laser rapid manufactured Ti porous structures (Principal Investigator) 2014-2017

Biphasic Hydroxyapatite based Keratoprosthesis in a rabbit model - Pilot study. (Principal investigator) 2013-2015

Medical device retrieval programme (Co-Principal Investigator) 2009-2013

Effect of cation substitution on the structure and biocompatibility of ionomer glasses and glass ceramics. (Principal Co-investigator) 2009-2012

Development of biomimetic strontium incorporated nanostructured ceramic coatings on Cp Titanium for orthopaedic implants (Co- Investigator) 2015-2018

Bioresorbable nanoporous bioceramics matrices for drug delivery in osteoporosis management. (Co- Investigator) 2013-2017

Molecular and immuno-toxicological effects of Dextran coated Ferrite and Hydroxylapitite nanomaterials (Co-investigator ) 2012-2015

Evaluation of Bioengineered cell sheet in rabbit model of total limbal stem cell deficiency. (Co-investigator) 2009-2012

Biofunctional evaluation of Supralimus-Core drug eluting coronary stents in porcine coronary artery model: Part B ???Histopathological evaluation. (Co-investigator) 2011

Evaluation of biocompatibility of materials as per ISO 10993 standards. Materials include metals, polymers, ceramics, composites and natural materials in subcutaneous tissue, muscle and bone of guinea pigs, rats and rabbits.

Preclinical evaluation of medical devices includes coronary stents (bare, drug eluting, degradable), small and large diameter vascular grafts, mechanical (Chitra-TTK mechanical heart valve) and biological heart valves, Annuloplasty ring, haemoconcentrator, oxygenator, blood centrifugal pump, Left Ventricular Assist Device, decellularised tissue conduits as Right ventricular outflow tract (RVOT) correction device in sheep and pig models. Orthodontic screws, PCL-Gel and Polyurethane based dural substitute, ureteric stents, bone graft implants, glass ionomer dental filler implants, neuroprosthetics, liquid neuroembolisation agents, decellularised scaffolds, wound care products, PCL-PLGC tissue engineered vascular grafts, osteochondral plugs, corneal cell sheets and keratoprosthesis

Participated five day exposure to scientific labs/ institutions in Taiwan from 30th May 2010 to 6th June 2010 under National programme for training of scientists and technologists working in Govt. Sector organized by Department of Science and Technology, GOI

Attended the five days course on Descriptive Veterinary Pathology sponsored by Armed Forces Institute of Pathology and CL Davis DVM foundation, USA. held at VIMTA LAB, Hyderabad, India from 2-6th April 2010

VIII th Foundation training programme for scientist and technologists, Nov 3rd 2008 to Jan 23rd 2009. Conducted at Indian Institute of Public Administration (IIPA), Indraprastha, New Delhi 100 002. Organized by Department of Science and Technology, GOI

Project management & application of Risk management to medical devices ISO14971. Organized by SCTIMST

GLP Study Audit training. Organized by SCTIMST

Training course on Laboratory Quality Management System and Internal Audit as per ISO/IEC 17025:2005. Organized by SCTIMST

CDSCO, DCGI, Govt of India approved Histopathology laboratory for medical device testing

Implementing quality management system at Histopathology laboratory for Biological evaluation of medical devices as per ISO17025 standard, with COFRAC accreditation.

Medical Device Retrieval Programme

Biological Evaluation of biomaterials.

Attented the University to Industry Technology Transfers in the Indian Context a DST sponsored Brain Storming meeting held on February 17-18, 2017 at BVRIT Hyderabad College of Engineering for Women, Hyderabad

Regulatory Toxicologic Pathology course conducted as Deputy course director. Module I - General Pathology and Toxicologic Pathology of Cardiovascular, Nervous and Urinary systems, 08th to 11th February, 2017

Module II - Toxicologic Pathology of Hepatobiliary system, Gastrointestinal system and respiratory systems, 03rd to 06th August, 2017

Module III - Immunotoxicologicpathology, Toxicologic pathology of male and female genital systems (including foetal pathology) and endocrine system, 08th to10 th February, 2018

Module IV Toxicologic Pathology of Skin & Musculoskeletal system and Toxicologic Pathology of Biomedical Devices 09th to 11th August, 2018

Sabareeswaran Arumugam

Joseph Sebestian

V.Vishwanadhan Nayak

Presented a poster in the 4th Nano Today Conference held at on Dec 6-10, 2015, DUBAI. UAE A. Sabareeswaran (1) presenting E.B. Ansar, P.V. Mohanan, P.R. Harikrishna varma, T.V. Kumary. Mast cell infiltration and oxidative stress induction of dextran and polyethylene glycol coated superparamagnetic iron oxide nanoparticles: an acute in vivo study

Resource person in TEQIP III sponsored seminar on Advanced biomaterials for Biomedical Application conducted by Dept of Medical Electronics, BMSCE, Bangalore- ???Biocompatibility evaluation and preclinical testing??? 17th to 22nd March, 2021

Resource person in International web course conducted by Lakhimpur College of Veterinary Science under Assam Agricultural University International web-course on ???Preclinical studies in biomedical research and regenerative medicine??? 24th to 30th August, 2020

Resource person in International web course ??????Recent Advancements in Biomaterials and Bioscience(RABB)?????? in association with the Department of Analytical Chemistry, University of Madras, Tamil Nadu, India, and Society for Biomaterials and Artificial Organs, Chennai Chapter. 27 to 31st of July 2020

Invited talk on the topic ???Tissue interactions to biomaterials??? at Pushphagiri research centre, Thiruvalla on 23rd Feb 2018

The evaluation of biomedical devices in preclinical studies at Department of veterinary Pathology, Madras veterinary College, TANUVAS. Chennai on 24th July 2017

Biomaterials in Tissue response to biomaterials and medical devices Medicinal Chemistry (BMC-2017) on April, 12 & 13, 2017 Dept of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu

Delivered an invited talk in the technical program of Indian Science Congress ISC 2014 held at Jammu ???Tissue response to biomaterials and medical devices??? on 6th February 2014

Invited to give a lecture on ???Tissue ???material interaction and local effects of implant??? at IISc, Bangalore as part of their UGC sponsored training programme on 24th May 2014

Delivered an invited talk at Department of Biomedical Engineering, PSG College of Technology as part of TEQIP sponsored one week Faculty Development Programme on ???Advances in molecular diagnostics and therapeutics??? with special emphasis on cancer, medical devices, and etc. during August 18 ??? 24, 2014

Invited to give a lecture on ???Necropsy and Histology in Biomedical Research??? at RGCB, Trivandrumin 2013 as part of their graduate training programme

Given a talk on 'Innate and adaptive immunity- Recent understandings and immune response to biomaterials and medical devices' at st Thomas college, Kozhenchery.Kerala. National seminar on current concepts in immunology 18-19 August 2011

Given a talk at University of Birmingham on 'The importance of evaluation of tissue-material interactions, both pre and post clinical' during the exchange visit in December 2010

Mira Mohanty, Sabareeswaran. A, Sulekha Baby, Joseph Sebastian and Caroline S Diana (2013), Color Atlas of Tissue Response to Biomaterials. JayPee Publishers; New Delhi. http://www.jaypeedigital.com/Book/BookDetail?isbn=9789350907382

Long term osseointegration study of sandblasted acid etched (sla) titanium implants with surface modification by hydroxy apatite(ha) and diamond like carbon(dlc) coating in rabbit model- Ms Neethu RS, MPhil dissertation thesis, Biomedical Technology, 2020

Study on Histological and gene expression profiles of rabbit burn wound treated with skin substitute Ms Athira, MPhil dissertation thesis, Biomedical Technology, 2019

Long term Osseointegration study of Laser Additive Manufactured Commercially Pure Titanium (LAM-Cp-Ti) Implants in Rabbit femur model by Histopathological and Molecular Analysis- Ms Gayathri R.S, M.Phil dissertation thesis, Biomedical Technology, 2018

Role of MicroRNA-29a,b,c in Bone Healing of Laser Additive Manufactured Commercially Pure Titanium Implants in Rabbit Model- Ms Sheenu A S, M.Phil dissertation thesis, Biomedical Technology, 2017

Osteogenic Studies of Drug Eluting Nanotubular Laser Additive Manufactured Commercially Pure Titanium- Ms R.Lekha, M.Phil dissertation thesis, Biomedical Technology, 2016

Ramakrishnan R, Harikrishnan VS, Anil A, Arumugham Sabareeswaran, Krishnan LK. Extracellular matrix-based combination scaffold for guided regeneration of large-area full-thickness rabbit burn wounds upon a single application. J Biomed Mater Res. 2021;1-14

Deepa Sathee, Sachin J Shenoy, Arya Anil, Sabareeswaran A, Lissy Kalliyana Krishnan. Combinatorial Application of Hyaluronic Acid and Curcumin-Albumin Conjugate for Cartilage Repair in TNF- alpha Induced Inflammation in Rabbit Knee Joint. Archives of Clinical and Biomedical Research 5 (2021): 519-537

Krishnapriya Chandrababu, Harikrishnan Vijayakumar Sreelatha, Tara Sudhadevi, Arya Anil, Sabareeswaran A & Lissy Kalliyana Krishnan (2021): In vivo neural tissue engineering using adipose-derived mesenchymal stem cells and fibrin matrix, The Journal of Spinal Cord Medicine, DOI: 10.1080/10790268.2021.1930369

Mayuri PV, Bhatt A, A Sabareeswaran, P Ramesh. An explicit correlation between surface functionality, wettability, and leukocyte removal by electrospun filter media. Materials Today Communications. 2021 Jan 26:102075

Vandana U, Nancy D, Sabareeswaran A, Remya NS, Rajendran N, Mohanan PV. Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications. Materials Science and Engineering: B. 2021 Feb 1;264:114954

Mayuri PV, Bhatt A, Sabareeswaran A, Ramesh P. Effect of membrane parameters and filter structure on the efficiency of leukocyte removal by electrospun poly (ethylene-co-vinyl alcohol) membranes. Journal of biomaterials science. Polymer edition.2020:1-8

Reshma VG, Sabareeswaran A, Rajeev KS, Mohanan PV. In vitro and In vivo toxicity analysis of Zinc Selenium/Zinc Sulfide (ZnSe/ZnS) Quantum dots. Food and Chemical Toxicology. 2020 Sep 3:111718

Ameer Jimna Mohamed, V Ramesh Babu, D Vinod, KV Nishad, A Sabareeswaran, PR Anil Kumar, Naresh Kasoju. Fabrication of co-cultured tissue constructs using a dual cell seeding compatible cell culture insert with a clip-on scaffold for potential regenerative medicine and toxicological screening applications. Journal of Science: Advanced Materials and Devices Volume 5, Issue 2, June 2020, Pages 207-217

Rashmi Ramakrishnan, Harikrishnan V. Sreelatha, Arya Anil, Sabareeswaran A,Prashanth Varkey, Manesh Senan, and Lissy K. Krishnan. Human-derived scaffold components and stem cells creating immunocompatible dermal tissue ensuing regulated nonfibrotic cellular phenotypes. ACS Biomater. Sci. Eng. 2020, 6, 5, 2740???2756

Subha S, Shenoy SJ, Anil A, Sabareeswaran A, Deepthi AN, Krishnan LK. Fibrin hydrogel aided cardiac progenitor cell delivery enhances regenerative tendency in myocardial infarct model. Archives of Clinical and Biomedical Research. 2020;4(5):513-41

Vijayan A, Sabareeswaran A, Kumar GV. PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing. Scientific Reports. 2019 Dec 16;9(1):1-2

Cherian RS, Anju S, Paul W, Sabareeswaran A, Mohanan PV. Organ distribution and biological compatibility of surface-functionalized reduced graphene oxide. Nanotechnology. 2019 Nov 20;31(7):075303

Elizabeth Vinod, Jithu Varghese James, A Sabareeswaran, Soosai Manickam Amirtham, George Thomas, Solomon Sathishkumar, Ozlem Ozbey, P.R.J.V.C. Boopalan, Intra articular injection of allogenic chondroprogenitors for treatment of osteoarthritis in rabbit knee model, Journal of Clinical Orthopaedics and Trauma, Volume 10, Issue 1,2019, p16-23

Vaishnavi R, Joseph J, Prasanth MJ, Mohanty M, Sabareeswaran A. TLR-4 expression in corrosion metal debri induced hypoxic milieu around stainless steel fracture plates. Biomedical Physics & Engineering Express. 2018 Mar 7;4(3):035005

Mohan Neethu, Mohanan PV, Sabareeswaran A, Nair Prabha. Chitosan-hyaluronic acid hydrogel for cartilage repair. International Journal of Biological Macromolecules. 2017 Nov; Volume 104, 1936-45

Umashankar PR, Sabareeswaran A, Shenoy SJ. Long???term healing of mildly cross???linked decellularized bovine pericardial aortic patch. JBMR Part B: Applied Biomaterials. 2017 Oct 1;105(7):2145-52

Syama S, Paul W, Sabareeswaran A, Mohanan PV. Raman spectroscopy for the detection of organ distribution and clearance of PEGylated reduced graphene oxide and biological consequences. Biomaterials. 2017 Jul 31;131:121-30

Sandhya S, Mohanan PV, Sabareeswaran A, Varma HK, Komath M. Preclinical safety and efficacy evaluation of ???BioCaS???bioactive calcium sulfate bone cement. Biomedical Materials. 2017 Feb 3;12(1):15-22

Sabareeswaran A, Ansar EB, Varma PR, Mohanan PV, Kumary TV. Effect of surface-modified superparamagnetic iron oxide nanoparticles (SPIONS) on mast cell infiltration: An acute in vivo study. Nanomedicine: Nanotechnology, Biology and Medicine. 2016 Aug 31;12(6):1523-33

Basu B, Sabareeswaran A, Shenoy SJ. 2015. Biocompatibility property of 100% strontium-substituted SiO2???Al2O3???P2O5???CaO???CaF2 glass ceramics over 26 wks implantation in rabbit model: Histology and micro-Computed Tomography analysis. J Biomed Mater Res Part B Applied Biomaterials (2015) 103(6): 1168???79

Ariya Saraswathy, Shaiju S. Nazeer, Madhumol Jeevan, Nirmala Nimi, Sabareeswaran A, Vijayakumar S. Harikrishnan, P.R. Harikrishna Varma, Ramapurath S. Jayasree. Citrate coated iron oxide nanoparticles with enhanced relaxivity for in vivo magnetic resonance imaging of liver fibrosis. Colloids Surf B Biointerfaces (2014) 117: 216???224

Ariya Saraswathy, Shaiju S Nazeer, Nirmala Nimi, Sabareeswaran A, Sachin J Shenoy, Jayasree R.S. Synthesis and characterization of Dextran stabilized superparamagnetic iron oxide nanoparticles for in vivo MR imaging of liver fibrosis. Carbohydrate Polymers (2014) 101:760??? 768

Mathew V Kurian, Payanam R Umasankar, A Sabareeswaran, Sachin J Shenoy, Vijayakumar Subban and Mathew K Joseph. A new concept in the sewing rings for mechanical heart valves. Asian Cardiovasc Thorac Annals (2012) 20: 409-417

Sabareeswaran, A. Bikramjit Basu, Sachin J Shenoy, Zahira Jaffer, Naresh Saha and Artemis Stamboulis. Early osseointegration of a strontium containing glass ceramic in a rabbit model. Biomaterials (2013) 34: 9278-9286

Mathew V. Kurian, A Sabareeswaran, Muniraj Kanchanamala, Seetharaman Balachandran, Dhananjayan Mogileswari, Vijayakumar Subban. The Role of the Sewing Ring in Tissue Healing: A Pathologic Study of Explanted Mechanical Heart Valves. The Journal of Heart Valve Disease (2012) 21:253-259

Lizymol P. P, P. V. Mohanan, A. Sabareeswaran, V. Kalliyana Krishnan. Biological Evaluation of a New Organically Modified Ceramic-Based Dental Restorative Resin. Journal of Applied Polymer Science (2012) Vol. 125, 620???629

Yingying Huang, Subbu S. Venkatraman, Freddy Y.C. Boey, Eeva M. Lahti, P.R. Umashankar, Mira Mohanty, Sabareeswaran A, Laxmikant Khanolkar, Sudhir Vaishnav. In vitro and in vivo performance of a dual drug-eluting stent (DDES) Biomaterials 2010; 31: 4382-4391

Huang Y, Venkatraman SS, Boey FYC, Umashankar PR, Mohanty M and A Sabareeswaran. The short-term effect on restenosis and thrombosis of a Cobalt- Chromium stent eluting two drugs in a porcine coronary artery model. Journal of Interventional Cardiology 2009; 22: 466-78

Article

1
Ariya Saraswathy1,2,7, Shaiju S. Nazeer1,3,7, Nirmala Nimi1, Hema Santhakumar1, Parvathy Radhakrishnapillai Suma1, Kunnumpurathu Jibin1, Marina Victor1, Francis Boniface Fernandez4, Sabareeswaran Arumugam5, Sachin J. Shenoy6, P. R. Harikrishna Varma4 & Ramapurath S. Jayasree1, Asialoglycoprotein receptor targeted optical and magnetic resonance imaging and therapy of liver fibrosis using pullulan stabilized multi???functional iron oxide nanoprobe, Scientific Reports, 2021, 11:18324, https://doi.org/10.1038/s41598-021-97808-0
2
Deepa Sathee, Sachin J Shenoy, Arya Anil, Sabareeswaran A, Lissy Kalliyana Krishnan., Combinatorial Application of Hyaluronic Acid and Curcumin-Albumin Conjugate for Cartilage Repair in TNF- ?? Induced Inflammation in Rabbit Knee Joint., Archives of Clinical and Biomedical Research, 2021, 5: 519-537
3
Krishnapriya Chandrababu, Harikrishnan Vijayakumar Sreelatha, Tara Sudhadevi, Arya Anil, Sabareeswaran A & Lissy Kalliyana Krishnan, In vivo neural tissue engineering using adipose-derived mesenchymal stem cells and fibrin matrix, The Journal of Spinal Cord Medicine,, 2021, , DOI: 10.1080/10790268.2021.1930369
4
Mayuri PV, Bhatt A, A Sabareeswaran, P Ramesh., An explicit correlation between surface functionality, wettability, and leukocyte removal by electrospun filter media., Materials Today Communications., 2021, Jan 26:102075
5
Vandana U, Nancy D, Sabareeswaran A, Remya NS, Rajendran N, Mohanan PV., Biocompatibility of strontium incorporated ceramic coated titanium oxide implant indented for orthopaedic applications., Materials Science and Engineering: B., 2021, Feb 1;264:114954
6
Mayuri PV, Bhatt A, Sabareeswaran A, Ramesh P., Effect of membrane parameters and filter structure on the efficiency of leukocyte removal by electrospun poly (ethylene-co-vinyl alcohol) membranes., Journal of biomaterials science. Polymer edition., 2020, :1-8
7
Reshma VG, Sabareeswaran A, Rajeev KS, Mohanan PV., In vitro and In vivo toxicity analysis of Zinc Selenium/Zinc Sulfide (ZnSe/ZnS) Quantum dots., Food and Chemical Toxicology., 2020, Sep 3:111718
8
Ameer Jimna Mohamed, V Ramesh Babu, D Vinod, KV Nishad, A Sabareeswaran, PR Anil Kumar, Naresh Kasoju., Fabrication of co-cultured tissue constructs using a dual cell seeding compatible cell culture insert with a clip-on scaffold for potential regenerative medicine and toxicological screening applications., Journal of Science: Advanced Materials and Devices, 2020, Volume 5, Issue 2, Pages 207-217
9
Rashmi Ramakrishnan, Harikrishnan V. Sreelatha, Arya Anil, Sabareeswaran A,Prashanth Varkey, Manesh Senan, and Lissy K. Krishnan., Human-derived scaffold components and stem cells creating immunocompatible dermal tissue ensuing regulated nonfibrotic cellular phenotypes., ACS Biomater. Sci. Eng. ,, 2020, 6 (5) 2740???2756
10
Subha S, Shenoy SJ, Anil A, Sabareeswaran A, Deepthi AN, Krishnan LK., Fibrin hydrogel aided cardiac progenitor cell delivery enhances regenerative tendency in myocardial infarct model., Archives of Clinical and Biomedical Research., 2020, 4(5):513-41