Dr. S. Harikrishnan
Professor
Phone :
0471-2524457

Academic Qualifications

Fellowship in Coronary Interventions,Leeds University,U.K.-2005-6.

DNB (Cardiology) - National Board, Govt. of India - 1999.

DM (Cardiology) , SCTIMST - 1998.

MD (Gen. Medicine), University of Calicut - 1995.

MBBS , University of Kerala, Medical College, Trivandrum - 1991.

Professional Record

PH - LEADER (The Public Health Leadership and Implementation Academy) Programme - Emory University, Atlanta, USA - 2014 -15.

Worked as Consultant in Cardiology, Indira Gandhi Hospital, Maldives on deputation to initiate and develop the cardiology program in that country. 2005 January 1 to Sept 15.

Commonwealth Fellow in Interventional Cardiology, Leeds General Infirmary, U.K. 2005 - 2006.

Ten Day teaching Seminar on Cardiovascular Epidemiology and Prevention of the World Heart Federation - Beijing, China - August - September, 2004.

Additional Professor in Cardiology, SCTIMST since 1/05/2008.

Associate professor in Cardiology, SCTIMST 1/5/04-30/04/08.

Assistant professor in Cardiology, SCTIMST 30/4/00-30/4/04.

Consultant in cardiology, SCTIMST 2/2/1999 - 2/8/1999.

Resident in Cardiology, SCTIMST 1/1/1996 - 31/12/1998.

Awards

Won the best case award in the National Interventional Council meet of Cardiological Society of India -- Hyderabad, April 26, 2009.

Area of Interest

Interventional Cardiology -Structural heart disease interventions, Balloon Mitral Valvotomy.

Coronary Interventions, Coronary Physiology - FFR.

Heart Failure.

Cardiovascular disease Epidemiology

Current Activities

CLINICAL :(Includes teaching - DM cardiology program - intake of 6 candidates per year and Post-doctoral fellowship program in Interventional cardiology)

Catheter interventions:Coronary Interventions, Structural heart disease interventions, Valvular heart disease Interventions - mitral valvotomy. Interventional cardiology clinic - Thursdays.

Heart Failure :Comprehensive heart failure intervention program Heart Failure clinic - every Wednesday.

Fellowships

Commonwealth Fellowship in Interventional Cardiology.

Fellowship of the Royal College of Physicians, London (FRCP) - 2013.

Fellowship of the American College of Cardiology, ACC (FACC)- 2009.

Visiting scholar to the University of Sydney, Australia (2010)

On-going Projects

Trivandrum Heart Failure Cohort - First heart failure cohort in India, Supported by ICMR - PI of the project - One year follow-up data presented as a late breaking trial in World Congress of Acute Heart Failure - Seville, Spain May 24-27, 2015. (Role - PI)

ACS - QUIK - Acute coronary Syndrome Quality improvement in Kerala - NHLBI Funded study - Initiated on November 10, 2014. (Role - PI)

PROKERALA - Pulmonary Hypertension registry of Kerala - Funded by Cardiological Society of India. Started on January 1, 2015, To collect data of 2000 patients.(Role - PI)

MACE Registry - Management of Acute Coronary Event Registry - The national ACS registry pilot study initiated by ICMR - Indian Council for medical Research - Started November 2014. ( Role - PI, Nodal center in Kerala).

MicroRNAs in Essential Hypertension :Understanding the role of SNPs in miRNA binding sites in 3 UTRs of target candidate genes influencing blood pressure funded by DST ,Govt of India - DST No: SERB/LS-17/2013, In collaboration with Interuniversity Center for Genomics and Gene Technology, University of Kerala, Kariavattom. (Role Co-PI)

Comprehensive Heart Failure Intervention Program funded by ICMR - Funded by Indian Council for Medical Research as an adhoc research project..(Role - PI)

Influence of Genetic Polymorphisms in Warfarin Requirement in a South Indian Population. Initiated patient recruitment in July 2015 - (Role - PI)

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) - Funded by National Heart, Lung, and BloodInstitute (NHLBI). Started 2014 - ongoing - (Role - Co-PI)

A family based Randomized Controlled Trial of cardiovascular risk reduction in individuals with family history of premature coronary heart disease in India. DBT-WELLCOME Trust project - (Role - Co-PI)

Developing Patient Education Materials Related To Heart Failure.Funded by Center for chronic disease control, CCDC,NEWDELHI, - (Role - PI)

Projects Completed

Economic impact of ACS in household economic well-being. Multinational study, funded by IC Health, New Delhi, World Bank and WHO. - Results published.

UMPIRE: Use of a Multidrug Pill in Reducing Cardiovascular Events. (Funded by European Commission) Role - Site PI - SCTIMST, Trivandrum. - Results published.).

MACE Registry -Management of Acute Coronary Event registry - First nationwide registry of acute coronary syndrome in India initiated by ICMR - Role PI - Nodal center in Kerala, SCTIMST.

Kerala ACS registry - Largest ACS registry in India - Role - Regional co-ordinator in south Kerala, results published. (European Heart Journal 2013). Funding - Cardiological Society of India.

CSI KERALA CRP - (Cardiac Risk-factor Profile) study - PI, South Kerala arm - Data collection over. Results being analysed. Funding - Cardiological Society of India

Coronary Artery Disease in the Young - database of 5000 patients, supported by Kerala State Government, KGCSTE, Role - PI of the project, results presented in World Heart federation, World Congress of Cardiology, Melbourne, 2014.

Does Non -Regression of Pulmonary Hypertension Following Balloon Mitral Valvotomy Correlate with BMPR 2 Mutations? supported by Pulmonary vascular Research Institute, Canterbury, UK.

Books and Journals edited

Founder Editor-in-Chief - PULMONARY CIRCULATION (2011-2013) International Journal of the pulmonary vascular research Institute - PVRI www.pulmonarycirculation.org). Indexed in pubmed.

Percutaneous Mitral Valvotomy : Harikrishnan.S (ed), Jaypee brothers, New Delhi; First Edition 2012. Pages 443, Second edition in Press.

A Race against Time: The Challenge of Cardiovascular Disease in Developing Economies. (Second Edition). S Harikrishnan, Stephen Leeder, Mark Huffman, Jeemon P, D Prabhakaran: December 2014. Center for Chronic Disease Control. New Delhi.

Book Chapters :- Harikrishnan S, Sanjay G, Mitral Stenosis and Percutaneous Mitral Valvotomy. In Color Atlas of Clinical Cardiology, (Eds Levine Glenn) Jaypee Brothers, Philadelphia, USA 2014.

Book Chapters :- Harikrishnan.S, Sanjay G, Krishnakumar K. Balloon Mitral Valvotomy (Chapter on Percutaneous balloon valvuloplasy for Mitral stenosis -"Cardiac catheterization and imaging from Pediatric to Geriatrics" IB Vijayalakshmi, Jaypee Brothers New Delhi, in press 2014.

Book Chapters :- Binil Raj, Harikrishnan Sivadasan Pillai and Chandrasekharan Cheranellore Kartha Molecular Basis of Pulmonary Hypertension in Left Heart Failure, in the book Molecular Defects in Cardiovascular Disease, N.S. Dhalla et al. (eds.), Molecular Defects in Cardiovascular Disease, Springer , USA.

Publications

Article

1
Harikrishnan S, Sanjay G, Anees T, Viswanathan S, Vijayaraghavan G, Bahuleyan CG, Sreedharan M, Biju R, Nair T, Suresh K, Rao AC, Dalus D, Huffman MD, Jeemon P, Clinical presentation, management, in-hospital and 90-day outcomes of heart failure patients in Trivandrum, Kerala, India, Eur J Heart Fail, 2015, 10.1002/ejhf.283, http://www.ncbi.nlm.nih.gov/pubmed/26011246?dopt=Abstract
2
Lopes AA, Barst RJ, Haworth SG, Rabinovitch M, Al Dabbagh M, Del Cerro MJ, Harikrishnan S, Repair of congenital heart disease with associated pulmonary hypertension in children, Pulm Circ., 2014, 4(2):330-41, http://www.ncbi.nlm.nih.gov/pubmed/25006452
3
Harikrishnan S Pillai, Ganapathi Sanjay, Heart failure in South Asia, Curr Cardiol Rev, 2013, 9(2):102-11, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682394/
4
Mohanan PP, Mathew R, Harikrishnan S, Huffman MD, Prabhakaran D, Presentation, management, and outcomes of 25 748 acute coronary syndrome admissions in Kerala, India, Eur Heart J, 2013, 34(2):121-9., http://www.ncbi.nlm.nih.gov/pubmed/?term=Presentation%2C+management%2C+and+outcomes+of+25+748+acute+coronary+syndrome+admissions+in+Kerala%2C+India%3A
5
Harikrishnan S, Bimal F, Ajithkumar V, Bhat A, Titus T, Tharakan J, Percutaneous treatment of congenital coronary arteriovenous fistulas, J Interv Cardiol, 2011, 24(3):208-15, http://www.ncbi.nlm.nih.gov/pubmed/21649734
6
Huffman MD, Rao KD, Pichon-Riviere A, Zhao D, Harikrishnan S, Calcagno JI, Caporale JE, A cross-sectional study of the microeconomic impact of cardio- vascular disease hospitalization in four LMIC, PLoS One, 2011, 6(6):, http://www.ncbi.nlm.nih.gov/pubmed/?term=A+cross-sectional+study+of+the+microeconomic+impact+of+cardio-+vascular+disease+hospitalization+in+four+LMIC
7
Cerro MJD, Abman S, Diaz G, Freudenthal AH, Freudenthal F, Harikrishnan S,, A consensus approach to the classification of pediatric pulmonary hypertensive vascular disease, Pulm Circ, 2011, 1(2):286-98., http://www.ncbi.nlm.nih.gov/pubmed/?term=A+consensus+approach+to+the+classification+of+pediatric+pulmonary+hypertensive+vascular+disease
8
Harikrishnan.S, Ajithkumar V, Sivasankaran S, Percutaneous closure of RSOV, Eurointervention, 2010, 6(2):214-9., http://www.pcronline.com/eurointervention/login/?url_to=/eurointervention/download_pdf.php?issue=28th&article=34
9
S.Harikrishnan, Anil Bhat, J A Tharakan, T Titus, Ajith Kumar VK, S. Sivasankaran, Percutaneous Transvenous Mitral Commissurotomy Using Metallic Commissurotome, Journal of Invasive Cardiology , 2006, 18; 54-58., http://europepmc.org/abstract/MED/16446516
10
Harikrishnan, K. Nair, Percutaneous mitral valvotomy in juvenile mitral stenosis, Cath. and Cardiovasc intrevention, 2006, 67: 453-457, http://www.ncbi.nlm.nih.gov/pubmed/16489558