Dr. Roy Joseph
Scientist 'G'
Phone : 0471-2520275 (O), 2541399 (R), 9447000987 (Cell)

Ph.D; University of London, U.K; 2001.

M.Tech; Cochin University of Science and Technology, Kochi, Kerala; 1989.

M.Sc; Mahatma Gandhi University, Kottayam, Kerala; 1987.

B.Sc; Kerala University, Trivandrum, Kerala; 1985.

Scientist-G; SCTIMST, Trivandrum; 10 October 2013 - Current

Scientist-F; SCTIMST, Trivandrum; 10 October 2009 - 9 October 2013

Scientist-E; SCTIMST, Trivandrum; 10 October 2004 - 9 Octobber 2009.

Scientist-D; SCTIMST, Trivandrum; 10 October 1999 - 9 October 2004.

Scientist-C; SCTIMST, Trivandrum; 10 October 1995 - 9 October 1999.

Scientist-B; SCTIMST, Trivandrum; 10 October 1991 - 9 October 1995.

Senior Technical Assistant, National Aerospace Laboratories, Bangalore; September 1989-September 1991.

Winner of the 4th National Award for Technology Innovation (2014) (along with C.V. Muraleedharan, Scientist G (Sr. Grade)) in the category, 'Polymers in Public Health Care' for developing the technology entitled, 'Fluoropolymer Coated and Hydrogel Sealed Vascular Graft Implant' instituted by Ministry of Chemicals and Fertilizers, Department of Chemicals & Petrochemicals, Govt. of India.

Commonwealth Scholarship to do Ph.D. in the UK. (From 1998-2001) .

Visiting scientist at Interdisciplinary Research Centre in Biomedical Materials (IRC) Queen Mary, University of London, UK from Aug, 1994-Nov.1994: Under the INDO-UK Higher Education Link Scheme .

University II Rank for the M.Tech. Degree Course (1989).

GATE Scholarship, 1987.

Radiopaque polymers for embolization - liquid embolic systems and microspheres, Polymer-ceramic/bioglass composites, bioink for 3D bioprinting, cell-nanomaterial interactions, metal-curcumin complexes for medical applications, surface modification of medical devices, hydrogel systems, translational research.

Guiding Ph.D. and M.Tech. students.

Running the following research programs : Fluoropolymer coating on vascular graft for improved hemocompatibility, Hydrogel coating on vascular graft as an alternative to blood pre-clotting, Curcumin releasing formulations for various biomedical applications, Radiopaque polyurethanes for medical applications, Solubilization of curcumin for wound care.

Indian Patents Granted:

S.N. Pal, V.K. Krishnan and R. Joseph; A process for the preparation of a visible light cured composite for dental restorative purposes.; Indian Patent No. 181364 (The Gazette of India, May 30, 1998, page 711).

Roy Joseph, P. Ramesh and R. Sivakumar; A process for preparing rubber articles of low friction coefficient, Indian Patent No. 198257 granted on 13-01-2006.

Roy Joseph, Kiran Sukumaran; Inherently Radiopaque And Non-Toxic Polyurethane Composition, Patent No. 328102; date of grant: 24/12/2019.

Roy Joseph and Chirathodi Vaylappil Muraleedharan; A vascular graft sealed with biodegradable hydrogel and passivated by fluoropolymer coating, Patent No. 354385; date of grant: 23/12/2020

Roy Joseph and Gopika Valsalakumari Gopan; A non-cytotoxic diphenolic tetraiodocompound and method of preparation thereof, Patent No. 398081, Date of grant: 30/05/2022.

Roy Joseph and Praveen Kunjan Sobhan, Amino acid enriched tunable bioink formulation for multidimensional bioprinting and the process thereof, Patent No. 404518, Date of grant: 25/08/2022.

PCT Patent Applications Filed:

Roy Joseph and Praveen Kunjan Sobhan, Amino Acid Enriched Tunable Bioink Formulation For Multidimensional Bioprinting And The Process Thereof, Application No. PCT/IN2020/050026, dtd. 10/01/2020

Roy Joseph, Jayadevan Enakshy Rajan and Gopika Valsalakumari Gopan, A Radiopaque Polymeric Liquid Embolic System, Application No. PCT/IN2020/050317, dtd. 01.04.2020.

Indian Patent Applications Filed:

Roy Joseph and C. V. Muraleedharan, Polyester based implant materials with reduced thrombogenicity and a process for making the same, Application No.: 1972/CHE/2006, Date of filing: 27-10-2006

Roy Joseph and Kiran Sukumaran, Non-toxic polyurethane compositions with inherent radiation shielding capability and optical transparency, Application no.: 988/CHE/2012; Date of filing: 19/03/2012

Roy Joseph and Kiran Sukumaran, A composite for preparing radiation shielding materials, Application no.: 2002/CHE/2012; Date of filing: 21/05/2012.

Roy Joseph and Praveen Kunjan Sobhan, Tunable Bioink for 3D bioprinting and the process thereof, Application No. 201841020267, date of filing: 30/05/2018.

Roy Joseph and Praveen Kunjan Sobhan, Bioink formulation suitable for low temperature bioprinting, Application No. 201941006800, dtd. 21.02.2019.

Roy Joseph, Jayadevan Enakshy Rajan and Gopika Valsalakumari Gopan, A Radiopaque Polymeric Liquid Embolic System, Application No. 201941013381, dtd. 03 April 2019.

Anugya Bhatt, Naresh Kasoju, Roy Joseph, Lakshmi Thompil Somasekharan and Gayathri Prameela Jayachandran, Cell Growth Enhancing Bioink Formulation for 3D Bioprinted Constructs, Application No. 201941031304, dtd. 02/08/2019.

Arvind Kumar Prajapati, Roy Joseph and Jayadevan Enakshy Rajan, An In Vitro Nidus Device to Evaluate Liquid Embolic Agents, Application No. 201941037451, dtd. 17 September 2019.

Gijo Raj, Prakash Nair, Roy Joseph, Hariharan Venkat Easwer and Manoj Komath, A flexible and retractable closure device, with bending recovery properties, Application No. 202041052458, dtd. 02/12/2020.

Indian Design Registrations Applied:

1. Arvind Kumar Prajapati, Jayadevan Enakshy Rajan and Roy Joseph (2019), `In Vitro Arteriovenous Malformation Model for Liquid Embolic Agent Evaluation?, Indian Design Application No. 320214-001, dtd. 30-07-2019.

2. Arvind Kumar Prajapati, Jayadevan Enakshy Rajan and Roy Joseph (2019), `Lid Nidus Construct for Liquid Embolic Agent Evaluation?, Indian Design Application No. 320214-002, dtd. 30-07-2019.

3. Arvind Kumar Prajapati, Jayadevan Enakshy Rajan and Roy Joseph (2019), `Nidus in Nidus Construct for Liquid Embolic Agent Evaluation?, Indian Design Application No. 320214-003, dtd. 30-07-2019.

Member, American Chemical Society

Life member, Society for Polymer Science, India.

Life member, Materials Research Society of India.

Life Member, Society for Biomaterials and Artificial Internal Organs, India.

Life Member, Association of British Scholars, India.

Projects Ongoing as Principal Investigator

Extending the benefits of biomedical science & technology to SC and ST communities through all level participatory engagement ? SC components; Grant agency: Dept. of Science and Technology, Govt. of India; Amount: Rs. 3,11,43,360/-; Duration: 3 years; Start date: 01 July 2020.

Extending the benefits of biomedical science & technology to SC and ST communities through all level participatory engagement ? ST components; Grant agency: Dept. of Science and Technology, Govt. of India; Amount: Rs. 3,01,43,360/-; Duration: 3 years; Start date: 01 July 2020.

Analytical characterization; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: Rs. 26.418 lakhs; Start date: 20 Sept 2016; End date: 30 September 2022.

Projects Ongoing as Co-Investigator

Alginate dialdehyde - Gelatin as a post-surgical adhesion prevention material in cardiac surgery - Swine model (Project code at BMT Wing: 8207; Project number at hospital wing: 5451); Grant agency: Biotechnology Industry Research Assistance Council (BIRAC) funding under Promoting Academic Research Conversion to Enterprise (PACE); Amount: Rs. 49.041 lakhs; Duration: 2 years; Start date: 22 March 2022 (PI: Dr. Sowmva Ramanan).

Alginate dialdehyde ? Gelatin as a post-surgical adhesion prevention material in thoracic surgery: A proof of concept study in swine models (Project No. 6239); Grant agency: Technology Development Fund, SCTIMST, Trivandrum; Amount: Rs.6.58 lakhs; Duration: 2 years; Start date: 12 November 2020; (PI: Dr. Sachin J. Shenoy).

Projects completed as Principal Investigator

Radiopaque polymeric microspheres for embolotherapy; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: Rs. 34.52 Lakhs; Duration: 2 years 6 months; Start date: July 2018.

Development and evaluation of radiopaque liquid embolization device by chemical grafting of iodinated compounds onto the ethylene vinyl alcohol co-polymer; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: Rs. 60.652 lakhs; Duration: 4 years 1 month; Start date: April 2016.

Enteric coating and microencapsulation of PHE's antibodies; Grant agency: Public Health England, UK.; Amount: Rs. 6.9867 lakhs (UK Pounds 8000); Duration: One year; Start date: 30-Aug-2016; Name of the collaborator: Dr. April Roberts, PHE, UK.

Development of a Light Weight, Lead Free, Polymer Based Thyroid Collar for Medical and Dental Diagnostic Radiology; Grant agency: Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, New Delhi; Amount: Rs. 19.62 lakhs; Duration: 2 years; Start date: 07-08-2015; Name of the collaborator: Lt. Col. Manu S. Krishnan, INMAS, DRDO, New Delhi.

Biodegradation studies of fluoropolymer coated and hydrogel sealed vascular graft; Grant agency: M/s. TTK healthcare Ltd.; Amount: Rs. 5.51 lakhs; Duration: One year; Start date: 21-03-2015.

Toxicokinetic studies of fluoropolymer coated and hydrogel sealed vascular graft by in vitro methods; Grant agency: M/s. TTK healthcare Ltd.; Amount: Rs. 2.24 lakhs; Duration: One year; Start date: 21-03-2015.

Biological evaluation of fluoropassivated and gel sealed graft; Grant agency: Technology Development Fund, SCTIMST; Amount: Rs. 3.80 lakhs; Duration: One year; Start date: 16-03-2009.

Development of Mandibular advancement device for the treatment of obstructive sleep apnea; Grant agency: Technology Development Fund, SCTIMST; Amount: Rs. 9.98 lakhs; Duration: Two years; Start date: 04-05-2011.

Preclinical evaluation of fluoropassivated and hydrogel sealed vascular graft; Grant agency: TTK healthcare Ltd.; Amount: Rs. 27.50 lakhs; Duration: Two years; Start date: 15-05-2010.

Development and Evaluation of Surface Modified, Hydrogel Coated Medium & Large Diameter Vascular Graft; Grant agency: Dept. of Biotechnology, Govt. of India (Sanction order No. BT/PR9339/MED/32/08/2007 dtd. 14.03.2008); Amount: 18.052 lakhs; Duration: One year; Start date: 14.03.2008.

Biological Evaluation of Fluoropassivated and Gel Sealed Vascular Graft; Grant agency: Technology Development Fund, SCTIMST (Project No.: 6030GN); Amount: 3.80 lakhs; Duration: One year; Start date: 16-03-2009.

Coating and characterization of vascular graft With Hygrogel derived from oxidized alginate and gelatin; Grant agency: Technology Development Fund, SCTIMST (Project No.: 6017GN); Amount: Rs. 1.992 lakhs; Duration: One year; Start date: March 08, 2006.

Development of bone graft substitutes for spinal fusion surgery; Grant agency: Dept. of Science and Technology, Govt. of India (Sanction order No. DST No. SR/SO/HS-28/2003, dated 20.04.2005); Amount: Rs. 22,59,000/-; Duration: 3 years; Start date: 25th May 2005.

Fluoropassivation of polyester fabric for Improved tissue compatibility: a feasibility study; Grant agency: Technology Development Fund, SCTIMST (Project No.: 6002GN); Amount: Rs. 1.1143 lakhs; Duration: One year; Start date: 10-11-2004.

Projects completed as Co-Principal Investigator

Prevention of post-surgical adhesion-Role of Alginate dialdehyde-Gelatin hydrogel as a pericardial adhesion barrier in cardiac surgery; Grant agency: Technology Development Fund, SCTIMST, Trivandrum; Amount: Rs. 5.7424 lakhs; Duration: 17 months; Start date: 17 September 2018; (PI: Dr. Sowmya Ramanan, Assistant Professor, Dept. of CVTS, SCTIMST).

Parylene coating for implantable medical devices and device delivery systems; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: 95.75 lakhs; Start date: Aug 2018; End date: July 2021.

3D printing of skin tissue constructs for in vitro testing and applications; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: 143.20 lakhs; Start date: 02-07-2018; End date: 30-09-2021.

3D printing of liver tissue constructs for in vitro hepatotoxicity testing; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: 342.10 lakhs; Start date: 01-06-2016; End date: 15-11-2020.

Bioactive inter-vertebral spacers for lumbar fusion; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: Rs. 31.23 lakhs; Start date: 01-06-2016; End date: 31-08-2018.

Development of aortic stent for endovascular treatment of thoracic aortic aneurism; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: Rs. 109.44 lakhs; Start date: 01-06-2016; End date: 31-12-2021.

Projects completed as Co-Investigator

Development of skull base buttress device for the closure of osteodural defect; Grant agency: Technology Development Fund, SCTIMST, Trivandrum; Amount: Rs. 4,88 lakhs; Duration: 18 months; Start date: 17 September 2018; (PI: Dr. Prakash Nair, Associate Professor, Neurosurgery Dept., SCTIMST).

Design and fabrication of head phantom for dosimetric evaluation of radiotherapy treatment plans; Grant agency: Kerala State Council for Science Technology and Environment, Kerala; Amount: Rs. 29.34 lakhs; Duration: 3 years 3 months; Start date: 01-April 2018; End date: 30-Jun-2021; Collaborator (PI): Dr. Shaiju V.S., Regional Cancer Centre, Trivandrum.

Development of left ventricular assist device; Grant agency: DST, Technical Research Center Scheme, SCTIMST, Trivandrum; Amount: 245.26 lakhs; Start date: 01-06-2016; End date: 30-06-2021.

Development of ceramic coated coronary stent system; Grant agency: CSIR-New Millennium Technology Leadership Initiative; Amount: Rs. 1.83 crores; Duration: 5 years; Start date: 2008.

PhD students and their research topic

1. Ms. Dhanya C. S.; An investigation into interfacial interaction of nanoparticles with cells and its ability to deliver drugs.

2. Ms. Resmi R. ; Alginate Based Cell Seeded Hydrogel Scaffold for Meniscal Repair: Development and Evaluation

3. Ms. Gopika Ramesh; Gallium-curcumin complexes for fighting bacterial resistance.

4. Ms. Gopika V. Gopan; Radiopaque iodinated compound grafted polymer: Synthesis and evaluation for embolotherapy.

5. Mr. Saravana Perumal R.; Design, Development, and Evaluation of Bio-Ink formulations for 3D bioprinting of skin construct.

6. Mr. Jithin Krishnan; Characterization of a hybrid electrode for deep brain stimulator applications with stimulation and sensing engineered within, enabling closed loop and adaptive control over stimulations.

7. Ms. Eliza Divya Srishty Minz; Polymeric embolic materials having radiocontrast properties: An investigation into the functional as well as biological response.

Article

1
Anjali, S.; Resmi, R.; Saravana, R.P. ; Joseph, R.; Saraswathy, M., Ferulic Acid Incorporated Anti-Microbial Self Cross Linking Hydrogel: A Promising System for Moderately Exudating Wounds, Journal of Drug Delivery Science and Technology, 2022, 73, 103446., https://doi.org/10.1016/j.jddst.2022.103446
2
Ramesh, G.; Kaviyil, J.E.; Paul, W.; Sasi, R.; Joseph, R., Gallium?Curcumin Nanoparticle Conjugates as an Antibacterial Agent against Pseudomonas aeruginosa: Synthesis and Characterization, ACS Omega, 2022, 7(8), 6795-6809., https://doi.org/10.1021/acsomega.1c06398
3
Adarsh Rajeswari Krishnankutty, Shamna Najeema Sulaiman, Arun Sadasivan, Roy Joseph and Manoj Komath, Porous membranes of quaternised chitosan composited with strontium based nanobioceramic for periodontal tissue regeneration, Journal of Biomaterials Applications, 2022, 36 (7), 1254-1268., https://doi.org/10.1177/08853282211050271
4
Resmi, R.; Parvathy, J.; Saravana, R.P.; Raj, G.; Joseph, R., Biosynthesized nanosilver from alginate dialdehyde: an in vitro evaluation, ChemistrySelect, 2021, 6 (43), 12007-12017., https://doi.org/10.1002/slct.202103220
5
Sasi, R.; Sreejith, S.L.; Ramesh, G.; Sherin, D.R.; Kaviyil, J.E.; Paul, W.; Joseph, R., Ionic liquid based antimicrobial coating on polymeric surface: A green chemistry approach, Results in Surfaces and Interfaces, 2021, 5, 100026., https://doi.org/10.1016/j.rsurfi.2021.100026
6
Gopan, G.V.; Susan, K.K.; Jayadevan, E.R.; Joseph, R., Organic compound with potential for X-ray imaging applications, ACS Omega, 2021, 6 (38), 24826-24833., https://doi.org/10.1021/acsomega.1c03671
7
Dhanya, C.S.; Paul, W.; Victor, S.P.; Joseph, R., On Improving the Physiological Stability of Curcuminoids: Curcumininoid-Silver Nanoparticle Complex as a Better and Efficient Therapeutic Agent, Nano-Structures & Nano-Objects, 2021, 25, 100661., https://doi.org/10.1016/j.nanoso.2020.100661
8
Resmi, R.; Anusree, K.S.; Joseph, R.; Bhatt, A., Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde?gelatin hydrogel, International Journal of Biological Macromolecules, 2021, 166, 999-1008., https://doi.org/10.1016/j.ijbiomac.2020.10.256
9
Sreejith, S.L.; Aswathy, B.P.; Joseph R.; Sasi, R., Size Exclusion Chromatography: An Effective Tool for the Estimation of Sirolimus Levels, Journal of Chromatography B, 2020, 1156, 122303, https://doi.org/10.1016/j.jchromb.2020.122303
10
Resmi, R.; Parvathy, J.; John, A.; Joseph, R., Injectable self-crosslinking hydrogels for meniscal repair: A study with oxidized alginate and gelatin, Carbohydrate Polymers, 2020, 234, 115902, https://doi.org/10.1016/j.carbpol.2020.115902